Polyvinylpyrrolidone K30 was used as the templating agent, and ammonium bicarbonate was used as the pore-forming agent to make porous mannitol and porous lactose by the template and pore-forming agent method, respectively. Compared with the template method, the porous particles prepared by the pore-forming agent method have larger pore diameter (320.276 nm and 250.528 nm) and specific surface area (1.018 m/g and 0.913 m/g). The molecular docking results showed that mannitol/lactose interacted with curcumin and adhered to each other through hydrogen bonding. The adsorption kinetics process of porous mannitol and porous lactose prepared by template agent, pore-forming agent and curcumin were different. Among the curcumin-loaded porous particles prepared by the two methods, the curcumin-loaded porous lactose prepared by the pore-forming agent method had the fastest release rate and the highest cumulative release rate (95 %). Curcumin releases consistent with the Peppas release kinetics model and the diffusion mechanism.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodres.2024.115496DOI Listing

Publication Analysis

Top Keywords

pore-forming agent
24
agent method
20
porous lactose
16
porous mannitol
12
mannitol porous
12
porous
9
agent
9
lactose template
8
template agent
8
porous particles
8

Similar Publications

Characterization, adsorption kinetic and in vitro release behavior of curcumin loaded with porous mannitol and porous lactose: Template agent method vs. Pore-forming agent method.

Food Res Int

January 2025

Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China. Electronic address:

Polyvinylpyrrolidone K30 was used as the templating agent, and ammonium bicarbonate was used as the pore-forming agent to make porous mannitol and porous lactose by the template and pore-forming agent method, respectively. Compared with the template method, the porous particles prepared by the pore-forming agent method have larger pore diameter (320.276 nm and 250.

View Article and Find Full Text PDF

The ApxIVA protein belongs to a distinct class of a "clip and link" activity of Repeat-in-ToXin (RTX) exoproteins. Along with the three other pore-forming RTX toxins (ApxI, ApxII and ApxIII), ApxIVA serves as a major virulence factor of Actinobacillus pleuropneumoniae, the causative agent of porcine pneumonia. The gene encoding ApxIVA is located on a bicistronic operon downstream of the orf1 gene and is expressed exclusively under in vivo conditions.

View Article and Find Full Text PDF

Introduction: This study aims to develop immediate release tablet formulations of lornoxicam (LRX) using hot melt extrusion (HME)-based fused deposition modeling (FDM) focusing on the adjustment of drug release by arranging infill densities and evaluating microcrystalline cellulose II (MCC II) as a disintegrating agent for HME-FDM purposes. LRX is a poorly soluble drug that exhibits pH-dependent solubility with a high thermal degradation temperature. These characteristics make it an ideal model drug for the HME-based FDM technique.

View Article and Find Full Text PDF

In the present study, porous calcium alginate films have been developed by the addition of 0.02, 0.1, and 0.

View Article and Find Full Text PDF

Enhancing the corrosion resistance of waterborne epoxy coatings with functionalized biochar.

RSC Adv

December 2024

Inner Mongolia Key Laboratory of New Materials and Surface Engineering, School of Materials Science and Engineering, Inner Mongolia University of Technology Hohhot 010051 China

Article Synopsis
  • The study repurposes discarded tree leaves to create biomass porous carbon nanosheets (PCNS) using high-temperature carbonization, which are then modified with carboxymethyl chitosan (CMCS) and a corrosion inhibitor.
  • Incorporating these functionalized PCNS into water-based epoxy (WEP) coatings significantly enhances their corrosion resistance, as shown by electrochemical impedance spectroscopy (EIS) results after 60 days.
  • The research highlights that CMCS captures chloride ions while improving PCNS dispersion in WEP, working alongside the corrosion inhibitor 8-hydroxyquinoline to provide a greener solution for effective corrosion protection.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!