Zwitterionic polymers exhibit strong hydration, high biocompatibility, and antifouling properties. Dendrimers are regularly branched polymers, which are used in the drug delivery system (DDS). In this study, we synthesized zwitterionic monomer- and polymer-conjugated dendrimers as a biocompatible nanoparticle to investigate the relation between the hydration property and biodistribution. A sulfobetaine monomer (SBM) was conjugated at the termini of the polyamidoamine (PAMAM) dendrimer. Polysulfobetaines (PSBs) were produced by reversible addition-fragmentation chain transfer polymerization and were also conjugated at the termini. Intermediate water, that is, water molecules loosely bound to the material, can be estimated from the melting peaks at less than 0 °C in differential scanning calorimetry (DSC) measurement. Our DSC results showed that the PSB-conjugated dendrimers (PSM-dens) contained more intermediate water than the SBM-conjugated dendrimer (SBM-den). PSB-dens accumulated in the tumor after intravenous administration, but SBM-den did not. These suggested that the amount of intermediate water, that is, the hydration property, was related to the biodistribution of the zwitterionic dendrimers. This relation is a possible design criterion for drug carriers. PSB-dens accumulated in the tumor even after the second injection, possibly overcoming the accelerated blood clearance observed with poly(ethylene glycol)-modified nanoparticles. Thus, this kind of zwitterionic polymer-conjugated dendrimer is useful for the DDS in cancer treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.langmuir.4c04276 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755784 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Nearly Barrierless Four-Hole Water Oxidation Catalysis on Semiconductor Photoanodes with High Density of Accumulated Surface Holes.
J Am Chem Soc
January 2025
Key Laboratory of Photochemistry, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
The sluggish water oxidation reaction (WOR) is considered the kinetic bottleneck of artificial photosynthesis due to the complicated four-electron and four-proton transfer process. Herein, we find that the WOR can be kinetically nearly barrierless on four representative photoanodes (i.e.
View Article and Find Full Text PDFFlexible Tail of Antimicrobial Peptide PGLa Facilitates Water Pore Formation in Membranes.
J Phys Chem B
January 2025
Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical, Biology College of Chemistry, Nankai University, Tianjin 300071, China.
PGLa, an antimicrobial peptide (AMP), primarily exerts its antibacterial effects by disrupting bacterial cell membrane integrity. Previous theoretical studies mainly focused on the binding mechanism of PGLa with membranes, while the mechanism of water pore formation induced by PGLa peptides, especially the role of structural flexibility in the process, remains unclear. In this study, using all-atom simulations, we investigated the entire process of membrane deformation caused by the interaction of PGLa with an anionic cell membrane composed of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG).
View Article and Find Full Text PDFFrom water to land-Usage of Generalized Unified Threshold models of Survival (GUTS) in an above-ground terrestrial context exemplified by honeybee survival data.
Environ Toxicol Chem
January 2025
Osnabrück University, Osnabrück, Lower Saxony, Germany.
In regulatory aquatic risk assessment, toxicokinetic-toxicodynamic (TKTD) methods, such as the generalized unified threshold model of survival (GUTS), are already established and considered ready for use, whereas TKTD methods for aboveground terrestrial species, like arthropods, are less developed and currently not intended for risk assessment. This could be due to the fact that exposure in aboveground terrestrial systems is more event-based (feeding, contact, overspray, etc.), whereas exposure in aquatic systems is simply related to substance concentrations in the surrounding water.
View Article and Find Full Text PDFButyl Imidates: Highly Stable and Isolable Synthetic Intermediates.
J Org Chem
January 2025
U.S. Process Chemistry, CMC Synthetics Platform, Sanofi, 350 Water Street, Cambridge, Massachusetts 02141, United States.
Imidates are versatile synthetic intermediates that contain ambiphilic reactivity, making them valuable pharmaceutically relevant synthons. Despite their extensive utility, imidates are typically generated in situ rather than isolated due to their inherent instability. This report details a systematic study that led to the discovery of an isolable imidate hydrogen chloride (HCl) salt that exhibits high tolerance to hydrolysis, thereby improving process control and facilitating downstream transformations.
View Article and Find Full Text PDFSwitching CO2 Electroreduction toward C2+ Products and CH4 by Regulate the Protonation and Dimerization in Platinum/Copper Catalysts.
Angew Chem Int Ed Engl
January 2025
Beijing Institute of Technology, Research Center of Materials Science, School of Materials Science and Engineering, No.5 South Street of Zhongguancun, Haidian District, 100081, Beijing, CHINA.
Copper (Cu)-based catalysts exhibit distinctive performance in the electrochemical CO2 reduction reaction (CO2RR) with complex mechanism and sophisticated types of products. The management of key intermediates *CO and *H is a necessary factor for achieving high product selectivity, but lack of efficient and versatile strategies. Herein, we designed Pt modified Cu catalysts to effectively modulate the competitive coverage of those intermediates.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!