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Another Note of Caution for Spironolactone: Implications of the BARACK-D Study.
Am J Kidney Dis
January 2025
Division of Nephrology, University of California, San Diego, San Diego, California; Department of Medicine, University of California, San Diego, San Diego, California; Veterans' Affairs Medical Center, San Diego, San Diego, California. Electronic address:
Neurobiology of COVID-19-Associated Psychosis/Schizophrenia: Implication of Epidermal Growth Factor Receptor Signaling.
Neuropsychopharmacol Rep
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Molecular Psychoneuroimmunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
COVID-19 exhibits not only respiratory symptoms but also neurological/psychiatric symptoms rarely including delirium/psychosis. Pathological studies on COVID-19 provide evidence that the cytokine storm, in particular (epidermal growth factor) EGF receptor (EGFR, ErbB1, Her1) activation, plays a central role in the progression of viral replication and lung fibrosis. Of note, SARS-CoV-2 virus (specifically, S1 spike domain) mimics EGF and directly transactivates EGFR, preceding the inflammatory process.
View Article and Find Full Text PDFOutcomes Following Direct Anterior Approach Total Hip Arthroplasty: A Contemporary Multicenter Study.
J Bone Joint Surg Am
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Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
Background: The direct anterior approach (DAA) is a popular approach for primary total hip arthroplasty (THA). However, the contemporary outcomes for DAA THA need further elucidation. Therefore, we aimed to describe implant survivorship, complications, and clinical outcomes after DAA THA.
View Article and Find Full Text PDFApproved and Emerging Hormone-Based Anti-Obesity Medications: A Review Article.
Indian J Endocrinol Metab
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Department of Endocrinology and Diabetes, Royal Glamorgan Hospital, Llantrisant, UK.
Obesity is a heterogeneous, complex, and chronic disease that has a detrimental impact on disability-adjusted life years across the globe. Recent advancements in our understanding of gut-brain communication at the molecular level have driven the development of next-generation anti-obesity medications (AOMs). Glucagon-like peptide-1 receptor agonists (GLP1RAs) remain the front-runners in this rapidly evolving landscape of hormone-based AOMs.
View Article and Find Full Text PDFTNK2 Inhibitor (R)-9bMS Causes Polyploidization Through Mitotic Failure by Targeting Aurora B.
Cell Biochem Funct
December 2024
Laboratory of Biochemistry and Molecular Biology, Kyoto Pharmaceutical University, Kyoto, Japan.
TNK2 is a ubiquitously expressed nonreceptor-type tyrosine kinase. TNK2 participates in tumorigenesis, and TNK2 activation has been found in various cancers; therefore, TNK2 is a promising target for cancer chemotherapy. While the TNK2 inhibitor XMD16-5 is highly selective, it inhibits cytokinesis at higher concentrations by targeting Aurora B kinase, a key enzyme for cell division.
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