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BMAL1 improves assisted reproductive technology outcomes in patients with polycystic ovary syndrome by targeting BMP6 and regulating ovarian granulosa cell apoptosis.
J Assist Reprod Genet
January 2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, Shandong, China.
Purpose: To investigate BMAL1 and BMP6 expressive differences in ovarian granulosa cells (OGCs) of patients with polycystic ovary syndrome (PCOS), explore regulatory relationship, assess their impacts on OGC proliferation and apoptosis, and analyze their correlations with ART outcomes of patients.
Methods: A clinical study selected 40 PCOS patients who underwent IVF/ICSI in our hospital from January to October 2022 and 39 controls with male or tubal factor infertility. RT-qPCR and Western blot assessed BMAL1 and BMP6 mRNA/protein levels.
Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency.
J Mol Med (Berl)
January 2025
Division of Human Reproduction and Developmental Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China.
Primary ovarian insufficiency (POI) is a disease defined as a reduction in ovarian function under the age of 40 and represents the main cause of female infertility. In recent years, many genetic mutations associated with POI have been identified using high-throughput sequencing technology. However, one big challenge today is to determine the disease-causing gene associations through functional assessment.
View Article and Find Full Text PDFInfluence Mechanism of Vermicompost with Different Maturity on Atrazine Catabolism and Bacterial Community.
Toxics
January 2025
College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, China.
Atrazine causes serious contamination of agricultural soils and groundwater. This study investigated the influence mechanism of sterilized soil (CKs), unsterilized soil (CKn), sterilized soil amended with 45 (SsV1), 60 (SsV2), 75 (SsV3) days of vermicompost (the maturity days of vermicompost), and unsterilized soil amended with 45 (SnV1), 60 (SnV2), 75 (SnV3) days of vermicompost on atrazine catabolism. The atrazine degradation experiment lasted for 40 days.
View Article and Find Full Text PDFAssociations of Urinary Perchlorate, Nitrate, and Thiocyanate with Female Infertility and Mediation of Obesity: Insights from NHANES 2013-2018.
Toxics
December 2024
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Classified as endocrine disrupting chemicals (EDCs), perchlorate, nitrate, and thiocyanate have been implicated with obesity and reproductive disorders. This study used three cycles of the National Health and Nutrition Examination Survey (NHANES 2013-2018); 813 women of reproductive age were finally included. We used multivariable logistic regression to analyze the associations between the three anions and obesity and infertility.
View Article and Find Full Text PDFEstablishment of Pathogen-Free Colonies Under Laboratory Conditions for the Vector Competence Studies.
Vet Sci
January 2025
Department of Parasitology, Faculty of Veterinary Medicine, University of Fırat, Elazığ 23200, Türkiye.
, the primary vector of , is also considered to transmit , , and spp. These claims are based on pathogen detections rather than experimental validation. To confirm vector competence, sterile ticks must acquire pathogens from infected hosts and transmit them to other hosts.
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