Gut Neuropathies and Intestinal Motility Disorders.

Neurogastroenterol Motil

College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Published: January 2025

Background: The enteric nervous system plays a key role in the coordination of gastrointestinal motility together with sympathetic, parasympathetic, and extrinsic sensory pathways. In some cases, abnormalities in neural activity in these pathways contribute to disorders of gut motility. Where this is associated with damage or death of enteric neurons, usually detected by microscopy, this is considered a gut neuropathy.

Purpose: This review summarizes recent advances in the identification of neuropathies in a range of gastrointestinal motility disorders.

Download full-text PDF

Source
http://dx.doi.org/10.1111/nmo.14995DOI Listing

Publication Analysis

Top Keywords

motility disorders
8
gastrointestinal motility
8
gut neuropathies
4
neuropathies intestinal
4
motility
4
intestinal motility
4
disorders background
4
background enteric
4
enteric nervous
4
nervous system
4

Similar Publications

Dementia Care Practice.

Alzheimers Dement

December 2024

Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.

"Dual Perspectives" integrates multiple MRI scans, creating a nuanced synthesis of grey matter and diffusion-based regional connections. This rendering holds particular significance in the realm of Alzheimer's and dementia research by offering a comprehensive examination of data crucial for understanding these complex neurodegenerative conditions. The inclusion of grey matter provides a detailed insight into the structural composition of the brain.

View Article and Find Full Text PDF

Regulation of INPP5E in Ciliogenesis, Development, and Disease.

Int J Biol Sci

January 2025

Department of Basic & Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA.

Inositol polyphosphate-5-phosphatase E (INPP5E) is a 5-phosphatase critically involved in diverse physiological processes, including embryonic development, neurological function, immune regulation, hemopoietic cell dynamics, and macrophage proliferation, differentiation, and phagocytosis. Mutations in cause Joubert and Meckel-Gruber syndromes in humans; these are characterized by brain malformations, microphthalmia, situs inversus, skeletal abnormalities, and polydactyly. Recent studies have demonstrated the key role of INPP5E in governing intracellular processes like endocytosis, exocytosis, vesicular trafficking, and membrane dynamics.

View Article and Find Full Text PDF

Achalasia cardia is a primary motility disorder of the esophagus marked by the absence of peristalsis and the failure of the lower esophageal sphincter (LES) to relax during swallowing. The preferred surgical approach is laparoscopic Heller's cardiomyotomy with Dor's fundoplication. Given the significant risks of mucosal perforation and the possibility of incomplete myotomy, which can lead to symptom recurrence, it is essential to ensure both the completeness of the myotomy and the preservation of the mucosal integrity.

View Article and Find Full Text PDF

Parkinsonism and Bilateral Facial Palsy after Chimeric Antigen Receptor T-Cell Therapy.

Mov Disord Clin Pract

January 2025

Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Dvision of Neurology, Toronto Western Hospital, UHN, Krembil Brain Institute, University of Toronto, Toronto, Ontario, Canada.

View Article and Find Full Text PDF

Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the second leading cause of cancer mortality. FAM49B, a member of the FAM49 gene family, is a recently identified, evolutionarily conserved gene. Emerging studies indicate that FAM49B plays a role in various cancers, though its specific mechanism in CRC remains largely unexplored.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!