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Olanzapine as an antidote in serotonin toxicity.
Br J Clin Pharmacol
January 2025
Swedish Poisons Information Centre, Stockholm, Sweden.
Management of high-dose olanzapine poisoning in a young child under limited resource setting: a case report from Nepal.
Ann Med Surg (Lond)
December 2024
Department of Pediatrics and Adolescent Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Introduction: Olanzapine, an atypical antipsychotic, is widely used for treating psychiatric conditions such as schizophrenia and bipolar disorder. Accidental overdose in children is rare but can lead to severe clinical effects. This case report discusses the management of a 5-year-old male who accidently ingested 180 mg of olanzapine, the highest reported dose in a child around 5 year.
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Br J Clin Pharmacol
June 2024
New South Wales Poisons Information Centre, Sydney Children's Hospital, Sydney, New South Wales, Australia.
Serotonin syndrome (toxicity), resulting from an excessive accumulation of serotonin in the central nervous system, it can occur due to various factors such as the initiation of medication, overdose or drug interactions. Diagnosing serotonin toxicity presents challenges as there are no definitive criteria. This review delves into the pathophysiology, incidence, clinical assessment and management of serotonin toxicity, stressing the significance of promptly recognizing and managing severe cases.
View Article and Find Full Text PDFComa, Severe Hypotension, and Pinpoint Pupils After Olanzapine Intoxication in the Intensive Care Unit with Symptom Reversal After Administration of Flumazenil.
Am J Case Rep
December 2022
Department of Psychiatry, Sahlgrenska Academy, Gothenburg, Sweden.
BACKGROUND Olanzapine is an antipsychotic drug and is used in critical care to treat delirium. There is no known antidote to olanzapine intoxication. Overdosing olanzapine can cause, tremor, bradykinesia, hypotension somnolence, coma, and miosis.
View Article and Find Full Text PDFSystematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose.
Clin Toxicol (Phila)
December 2021
Emergency Department CISSS Montérégie Centre, Greenfield Park, Canada.
Article Synopsis
- The use of activated charcoal in treating poisonings has evolved, with initial declines in routine use due to new data on pharmaceuticals and gastric emptying times, leading to debates in toxicology.
- Major toxicology associations established the Clinical Toxicology Recommendations Collaborative to create evidence-based guidelines for managing poisoning cases.
- The primary aim of recent research was to assess whether activated charcoal improves outcomes in poisoned patients, alongside secondary goals of examining pharmacokinetic effects and potential adverse reactions.
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