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The type of diet consumed during prepuberty modulates plasma cholesterol, hepatic LXRα expression, and DNA methylation and hydroxymethylation during adulthood in male rats.
PLoS One
January 2025
Department of Nutritional Physiology, National Institute of Medical and Nutritional Sciences "Salvador Zubirán", Mexico City, Mexico.
Childhood obesity increases the risk of developing metabolic diseases in adulthood, since environmental stimuli during critical windows of development can impact on adult metabolic health. Studies demonstrating the effect of prepubertal diet on adult metabolic disease risk are still limited. We hypothesized that a prepubertal control diet (CD) protects the adult metabolic phenotype from diet-induced obesity (DIO), while a high-fat diet (HFD) would predispose to adult metabolic alterations.
View Article and Find Full Text PDFPrediction of stunting and its socioeconomic determinants among adolescent girls in Ethiopia using machine learning algorithms.
PLoS One
January 2025
Department of Health Informatics, School of Public Health, College of Medicine and Health Science, Woldia University, Woldia, Ethiopia.
Background: Stunting is a vital indicator of chronic undernutrition that reveals a failure to reach linear growth. Investigating growth and nutrition status during adolescence, in addition to infancy and childhood is very crucial. However, the available studies in Ethiopia have been usually focused in early childhood and they used the traditional stastical methods.
View Article and Find Full Text PDFExploring Developmental Connections: Sleep Patterns, Self-Locomotion, and Vocabulary Growth in Early Childhood.
Infancy
January 2025
Language and Linguistic Science Department, University of York, York, UK.
Current research indicates likely developmental connections between the evolution of sleep patterns, motor skills progression, and the expansion of vocabulary. These connections are grounded in the well-established role of sleep in memory and learning, as well as in the cascading effects on language development of the acquisition of new motor skills. However, no study has so far undertaken a comprehensive and systematic examination of these connections or explored their developmental trajectory over time.
View Article and Find Full Text PDFUSP39 promotes retinal pathological angiogenesis in retinopathy of prematurity by stabilizing SIRT2 expression through deubiquitination.
Int Ophthalmol
January 2025
Department of Ophthalmology, Xingtai People's Hospital, Xingtai, 054001, Hebei, China.
Background: Retinopathy of prematurity (ROP) is a major cause of childhood blindness worldwide, highlighted by retinal neovascularization. Ubiquitin is present throughout the retina. The deubiquitinating enzyme ubiquitin-specific protease 39 (USP39) has been reported to be involved in angiogenesis.
View Article and Find Full Text PDFInteraction effect of mobile gaming addiction and excessive sugar-sweetened beverage consumption on overweight and obesity among schoolchildren: Evidence from a large population-based study in Guangzhou, China.
J Behav Addict
January 2025
Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Objective: To explore the individual and interactive associations between mobile gaming addiction (MGA), excessive consumption of sugar-sweetened beverages (SSBs), and overweight/obesity among schoolchildren, and to investigate whether these interactions vary by gender or grade level.
Methods: Data were drawn from the Children's Growth Environment, Lifestyle, and Physical and Mental Health Development project (COHERENCE) conducted in Guangzhou, China, during the 2019/20 academic year. 418,197 children aged 6-12 years were included in the study.
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