[This corrects the article DOI: 10.1371/journal.pone.0307800.].
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316871 | PLOS |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684688 | PMC |
Alzheimers Dement
December 2024
Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.
Background: AD-NeuroScore is a validated metric that summarizes Alzheimer's disease (AD)-specific atrophy and can detect AD early, benchmark disease severity, predict and monitor AD progression, and can aid in testing the efficacy of therapeutic interventions using a single number (Kress, 2023). It meets criteria for translatability by using clinically available regional brain volumes as input (Ahdidan, 2015; Cavedo, 2022) and having patient and model-level interpretability (Pinto, 2022). Also, features can be reviewed by a neuroradiologist (Larson, 2019).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Background: Alzheimer's disease (AD) and related dementias can have long preclinical phases; thus, midlife intervention and prevention methods could prove efficacious. Multiple health-related lifestyle factors have been associated with risk for AD. However, research on lifestyle factors has focused on clinical outcomes such as cognitive decline, mild cognitive impairment and/or AD dementia; their associations with potential early changes in cerebrospinal fluid (CSF) biomarkers are less understood.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Background: This post-hoc sub-group analysis of the Japan-multimodal intervention trial for prevention of dementia (J-MINT) aimed to examine the efficacy of the multi-domain intervention in older adults with type 2 diabetes.
Method: J-MINT was an 18-month, randomized controlled trial. Participants aged 65-85 years with mild cognitive deficits were recruited and randomized into multidomain intervention (management of vascular risk factors, physical exercise, nutritional counseling, and cognitive training) and control groups (written health-related information every 2 months).
Alzheimers Dement
December 2024
Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Research Institute, Barcelona, Spain.
Background: Adhering to lifestyle-based multimodal interventions to prevent cognitive decline is crucial for their success, but limited evidence exists on determinants of adherence. This gap may stem from inconsistent adherence measurement and reporting across studies. Additionally, uncertainties persist regarding the optimal intervention intensity needed for meaningful cognitive benefits.
View Article and Find Full Text PDFPurpose: To evaluate residual refractive errors after intraocular lens (IOL) extraction and the safety and effectiveness of refractive correction procedures.
Methods: The eligibility criteria for this systematic review were patients who had undergone cataract or clear lens extraction and had experienced residual refractive error. All study designs were considered for inclusion and non-English publications, non-peer reviewed articles, books, and systematic reviews were excluded.
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