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Drug Development.
Alzheimers Dement
December 2024
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, NSW, Australia.
Background: Alzheimer's Disease (AD) poses a substantial global health burden, necessitating innovative therapeutic strategies. This study investigates the neuroprotective potential of a chrysin-loaded Nanostructured Lipid Carrier (NLC) drug delivery system in AD management. Employing the high-pressure homogenization method, chrysin-loaded NLCs were meticulously formulated to optimize drug delivery efficiency.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
University of Alabama in Huntsville, Huntsville, AL, USA.
Currently, there are no curative treatments for Alzheimer's Disease. It is crucial to develop screening tools that detect early signs of decline, allowing for timely interventions that may impede the progression of cognitive impairment. Neurospective is a mobile application platform designed to facilitate the early detection of cognitive decline, including mild cognitive impairment (MCI) and pre-clinical Alzheimer's disease and related dementias (ADRD).
View Article and Find Full Text PDFToward the Optimization of a Perovskite-Based Room Temperature Ozone Sensor: A Multifaceted Approach in Pursuit of Sensitivity, Stability, and Understanding of Mechanism.
Small
January 2025
Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas, Vassilika Vouton, Heraklion, 70013, Greece.
Metal halide perovskites (MHPs) have attracted significant attention owing to their simple manufacturing process and unique optoelectronic properties. Their reversible electrical or optical property changes in response to oxidizing or reducing environments make them prospective materials for gas detection technologies. Despite advancements in perovskite-based sensor research, the mechanisms behind perovskite-gas interactions, vital for sensor performance, are still inconclusive.
View Article and Find Full Text PDFGenetic Underpinnings of Oligoasthenoteratozoospermia.
Clin Genet
January 2025
School of Medicine, Yunnan University, Kunming, Yunnan, China.
Oligoasthenoteratozoospermia (OAT) is a frequent but severe type of male infertility. As one of the most multifaceted male infertility resulting from sperm problems, its genetic etiology remains unknown in most cases. In this review, we systematically sort out the latest literature on clinical reports and animal models leading to OAT, summarise the expression profiles of causative genes for OAT, and highlight the important role of the protein transport system during spermiogenesis, spermatid cell-specific genes, Golgi and acrosome-related genes, manchette-related genes, HTCA-related genes, and axoneme-related genes in OAT development.
View Article and Find Full Text PDFAugmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B gene adjuvant.
Virol J
January 2025
Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Therapeutic human papillomavirus (HPV) DNA vaccine is an attractive option to control existed HPV infection and related lesions. The two early viral oncoproteins, E6 and E7, are continuously expressed in most HPV-related pre- and cancerous cells, and are ideal targets for therapeutic vaccines. We have previously developed an HPV 16 DNA vaccine encoding a modified E7/HSP70 (mE7/HSP70) fusion protein, which demonstrated significant antitumor effects in murine models.
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