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Spermine Significantly Increases the Transfection Efficiency of Cationic Polymeric Gene Vectors.
Pharmaceutics
January 2025
School of Pharmacy, Changzhou University, Changzhou 213164, China.
Non-viral vectors have gained recognition for their ability to enhance the safety of gene delivery processes. Among these, polyethyleneimine (PEI) stands out as the most widely utilized cationic polymer due to its accessibility. Traditional methods of modifying PEI, such as ligand conjugation, chemical derivatization, and cross-linking, are associated with intricate preparation procedures, limited transfection efficiency, and suboptimal biocompatibility.
View Article and Find Full Text PDFBiomimetic Silicone Surfaces for Antibacterial Applications.
Polymers (Basel)
January 2025
Institute of Biochemistry and Genetics, Subdivision of the Ufa Federal Research Center of the Russian Academy of Sciences, Ufa 450054, Russia.
Biomimetic patterning emerges as a promising antibiotic-free approach to protect medical devices from bacterial adhesion and biofilm formation. The main advantage of this approach lies in its simplicity and scalability for industrial applications. In this study, we employ it to produce antibacterial coatings based on silicone materials, widely used in the healthcare industry.
View Article and Find Full Text PDFTwo- and Three-Dimensional In Vitro Models of Parkinson's and Alzheimer's Diseases: State-of-the-Art and Applications.
Int J Mol Sci
January 2025
Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad Las Palmas de Gran Canaria (ULPGC), Paseo Blas Cabrera Felipe "Físico" 17, 35016 Las Palmas de Gran Canaria, Spain.
In vitro models play a pivotal role in advancing our understanding of neurodegenerative diseases (NDs) such as Parkinson's and Alzheimer's disease (PD and AD). Traditionally, 2D cell cultures have been instrumental in elucidating the cellular mechanisms underlying these diseases. Cultured cells derived from patients or animal models provide valuable insights into the pathological processes at the cellular level.
View Article and Find Full Text PDFDesign and Fabrication of Ultrathin Metallic Phase Shifters for Visible and Near-Infrared Wavelengths.
Micromachines (Basel)
January 2025
State Key Laboratory of High-Performance Precision Manufacturing, Dalian University of Technology, Dalian 116024, China.
The polarization state of light is critical for biological imaging, acousto-optics, bio-navigation, and many other optical applications. Phase shifters are extensively researched for their applications in optics. The size of optical elements with phase delay that are made from natural birefringent materials is limited; however, fabricating waveplates from dielectric metamaterials is very complex and expensive.
View Article and Find Full Text PDFModel Organisms in Aging Research: Evolution of Database Annotation and Ortholog Discovery.
Genes (Basel)
December 2024
Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Background: This study aims to analyze the exploration degree of popular model organisms by utilizing annotations from the UniProtKB (Swiss-Prot) knowledge base. The research focuses on understanding the genomic and post-genomic data of various organisms, particularly in relation to aging as an integral model for studying the molecular mechanisms underlying pathological processes and physiological states.
Methods: Having characterized the organisms by selected parameters (numbers of gene splice variants, post-translational modifications, etc.
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