AB-Type Zwitterionic Hydrogel Paint.

Zwitterionic hydrogels exhibit excellent nonfouling and hemocompatibility. However, the practical application of these materials as antifouling coatings for biomedical devices is hindered by several key challenges, including the harsh preparation conditions and the weak coating stability. Here, we present a two-component zwitterionic hydrogel paint for the in situ preparation of robust zwitterionic hydrogel coatings on various substrate surfaces without UV assistance. It is performed by the curing and adhesion of a zwitterionic hydrogel simultaneously through the ring opening reaction of epoxy and amino inspired by the successful commercial two-component epoxy structural glue. The obtained AB-type PSBMA coating can withstand water flow velocities of up to 15 m/s and still maintain its structural integrity and functional stability. It is noteworthy that the coating preparation process does not require the use of any organic solvent, which greatly simplifies the postprocessing steps for its application in medical devices. Moreover, the coating not only resists bacterial and cell adhesion but also exhibits favorable hemocompatibility. This approach offers a novel concept for the design of zwitterionic hydrogel coatings for biomedical devices.