: Cancer remains one of the leading causes of death worldwide, and thus, there is a need for the development of innovative and more effective treatment strategies. The aim of the study was to evaluate two types of nanoparticles-nanospheres and micelles-obtained from PLA-based polymers to discover their potential for delivering four types of phenothiazine derivatives. : The morphology, drug-loading properties, cytocompatibility, hemolytic properties and anticancer activity were analyzed. : The micelles exhibited significantly higher drug-loading properties, release process and cytotoxic activity against cancer cells compared to the nanospheres. The micelles containing 5-methyl-12-quino[3,4-][1,4]benzothiazinium chloride with an OH group as a substituent in the 10-position of the quinobenzothiazine ring showed the highest drug-loading content, the most efficient drug release, the lowest hemolytic activity and the most significant cytotoxic effect against HeLa cells. : The conducted study enabled the development of a delivery system for the new anticancer compound and showed that the choice of drug carrier has a crucial effect on its cytotoxic potential against cancer cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676417 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics16121597 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lurasidone versus typical antipsychotics for schizophrenia.
Cochrane Database Syst Rev
January 2025
Section of Affective Disorders, Department of Psychiatry, Jagiellonian University Medical College, Krakow, Poland.
Background: Antipsychotic drugs are the mainstay of treatment for schizophrenia. Even though several novel second-generation antipsychotics (i.e.
View Article and Find Full Text PDFDeciphering the Photophysical Properties of Nonplanar Heterocyclic Compounds in Different Polarity Environments.
J Phys Chem B
January 2025
Materials Chemistry Department, CSIR-Institute of Minerals and Materials Technology, Bhubaneswar 751013, India.
Nonplanar (butterfly-shaped) phenothiazine () and its derivative's () photophysical and spectral properties have been tuned by varying the solvents and their polarity and investigated employing spectroscopic techniques such as UV-Vis, steady-state and time-resolved fluorescence, and TDDFT calculations. The UV-Vis absorption studies and TDDFT calculations reveal two distinct bands for both compounds: a strong π-π* transition at shorter wavelengths and a weaker -π* transition, which displays a little bathochromic shift in polar solvents. The detailed emission studies reveal that such dual emission is a result of the photoinduced excited-state conjugation enhancement (ESCE) process.
View Article and Find Full Text PDFNew Molecular Photoswitch Based on the Conformational Transition of Phenothiazine Derivatives and Corresponding Triplet Emission Properties.
J Am Chem Soc
January 2025
Institute of Molecular Aggregation Science, Tianjin University, Tianjin 300072, China.
Molecular photoswitch research has drawn much attention in the last century owing to its great potential in the development of smart materials. However, photoswitches suitable for constructing light-responsive luminescent materials remain limited, especially those involving triplet-state phosphorescence. Herein, we designed a novel molecular photoswitch based on the conformation transition of phenothiazine derivatives, minimizing steric hindrance (-CH > -Cl > -F) to regulate the conformation transition process while introducing a cyanobenzene acceptor to promote phosphorescence emission potential.
View Article and Find Full Text PDFExploring the Impact of Structural Modifications of Phenothiazine-Based Novel Compounds for Organic Solar Cells: DFT Investigations.
Polymers (Basel)
January 2025
Research Laboratory of Asymmetric Synthesis and Molecular Engineering of Materials for Organic Electronic (LR18ES19), Department of Physics, Faculty of Sciences of Monastir, University of Monastir, Avenue of Environment, Monastir 5019, Tunisia.
This paper explores a novel group of D-π-A configurations that has been specifically created for organic solar cell applications. In these material compounds, the phenothiazine, the furan, and two derivatives of the thienyl-fused IC group act as the donor, the π-conjugated spacer, and the end-group acceptors, respectively. We assess the impact of substituents by introducing bromine atoms at two potential substitution sites on each end-group acceptor (EG1 and EG2).
View Article and Find Full Text PDFExploring Micelles and Nanospheres as Delivery Systems for Phenothiazine Derivatives in Cancer Therapy.
Pharmaceutics
December 2024
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 Curie-Skłodowskiej St., 41-819 Zabrze, Poland.
: Cancer remains one of the leading causes of death worldwide, and thus, there is a need for the development of innovative and more effective treatment strategies. The aim of the study was to evaluate two types of nanoparticles-nanospheres and micelles-obtained from PLA-based polymers to discover their potential for delivering four types of phenothiazine derivatives. : The morphology, drug-loading properties, cytocompatibility, hemolytic properties and anticancer activity were analyzed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!