RNA therapeutics are a class of medicines based on the insertion of a specific genetic message (mRNA) into the cells and the silencing or gene editing of a specific mRNA [...].
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The TRIPOD-LLM reporting guideline for studies using large language models.
Nat Med
January 2025
Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Large language models (LLMs) are rapidly being adopted in healthcare, necessitating standardized reporting guidelines. We present transparent reporting of a multivariable model for individual prognosis or diagnosis (TRIPOD)-LLM, an extension of the TRIPOD + artificial intelligence statement, addressing the unique challenges of LLMs in biomedical applications. TRIPOD-LLM provides a comprehensive checklist of 19 main items and 50 subitems, covering key aspects from title to discussion.
View Article and Find Full Text PDFPrevention Is Better Than Cure: Public Understanding of Preventing Neurodegenerative Disorders.
Int J Geriatr Psychiatry
January 2025
Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Pharmacovigilance in the Community: A Special-Interest Group of the International Society of Pharmacovigilance.
Drug Saf
January 2025
International Society of Pharmacovigilance, Middle East Chapter, Dubai, UAE.
Bridging pediatric and adult IgAN: challenges in applying proteinuria-driven recommendations in the new IPNA guidelines.
Pediatr Nephrol
January 2025
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Videolaryngoscopy in paediatrics: in search of the clinical evidence.
Br J Anaesth
January 2025
Department of Anaesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Despite the numerous recent trials, systematic reviews and meta-analyses have not conclusively shown superiority of videolaryngoscopy over other techniques for tracheal intubation of children. Clinical trials have shown significant differences using various outcome measures, but the overall clinical evidence remains weak. An international group of experts is currently working on developing good clinical research practice guidelines for paediatric airway management research, with the ultimate aim of identifying a core set of outcomes to be applied to develop future robust and comparable trials.
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