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Background: Three herbal extracts ( Willd., Lorentz, and L.) were mixed with three essential oils ( Mill., L., and L.) to formulate a product (HEMEO) whose active compounds include saponins and steroids in , known for their anti-inflammatory properties; glycyrrhizin and flavonoids in , which exhibit gastroprotective and antispasmodic effects; menthol in , contributing with antispasmodic and antimicrobial properties; and anethole and polyphenols in , which modulate intestinal motility and offer antimicrobial activity.
Objective: HEMEO was formulated for applications in intestinal motility disorders.
Methods: HEMEO was evaluated for spontaneous and induced motility effects in isolated guinea pig ileum, colon, and stomach. Ex vivo experiments were conducted using LabChart software v7.0, and the product's antibacterial action against and its antioxidant effects were assessed through disc diffusion and FRAP assays. The presence of the volatile compounds in the formulation was confirmed by GC-MS analysis; the TPC of HEMEO, determined using the Folin-Ciocalteu method, was 9.925 ± 0.42 mg GAE/g.
Conclusions: HEMEO showed a phenolic content correlated with its antioxidant potential and in addition inhibited growth and demonstrated notable antioxidant properties, suggesting its role as a supportive agent in digestive processes and in managing motility disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677010 | PMC |
| http://dx.doi.org/10.3390/nu16244357 | DOI Listing |
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