The goal of research in the post-genomic era, now that the full extent of the genes encoded on microbial genomes is known [https://www [...].
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SNX30 inhibits lung adenocarcinoma cell proliferation and induces cell ferroptosis through regulating SETDB1.
J Cardiothorac Surg
January 2025
Department of Respiratory and Critical Care Medicine, Datian County General Hospital, 180 Xueshan North Road, Datian County, 366100, China.
Background: Lung adenocarcinoma is the most common form of lung cancer and one of the most life-threatening malignant tumors. Ferroptosis is an iron-dependent regulatory cell death pathway that is crucial for tumor growth. SNX30 is a key regulatory factor in cardiac development; however, its regulatory mechanism and role in inducing ferroptosis in lung adenocarcinoma remain unclear.
View Article and Find Full Text PDFYoung people's proposals for tackling everyday challenges in order to improve mental health: a qualitative comparison study based on different socioeconomic neighborhoods.
BMC Public Health
January 2025
Department of Care Science, Faculty of Health and Society, Malmö University, Malmö, Sweden.
Background: Everyday challenges and stress negatively affect young people's mental health. Socioeconomic status (SES) is associated with different stressors and different stress-coping mechanisms. Many interventions target youth mental health, but few consider socioeconomic differences in the planning, implementation, or evaluation.
View Article and Find Full Text PDFPhylogeny-based comparative analysis of gene expression modulation upon drought stress across three cotton diploids.
BMC Plant Biol
January 2025
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
Background: Drought stress is a significant global challenge that negatively impacts cotton fiber yield and quality. Although many drought-stress responsive genes have been identified in cotton species (Gossypium spp.), the diversity of drought response mechanisms across cotton species remains largely unexplored.
View Article and Find Full Text PDFGentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation.
Acta Pharmacol Sin
January 2025
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Psoriasis is a chronic, systemic immune-mediated skin disease. Although many new strategies for psoriasis treatment have been developed, there is great need in clinic for treating psoriasis. Gentiopicroside (GPS), derived from Gentiana manshurica Kitagawa, has multiple pharmacological activities including anti-inflammatory, anti-oxidative and antiviral activities.
View Article and Find Full Text PDFGene regulation by convergent promoters.
Nat Genet
January 2025
Hoffmann Lab, Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany.
Convergent transcription, that is, the collision of sense and antisense transcription, is ubiquitous in mammalian genomes and believed to diminish RNA expression. Recently, antisense transcription downstream of promoters was found to be surprisingly prevalent. However, functional characteristics of affected promoters are poorly investigated.
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