Defect detection and classification in super-high reflector mirrors and their substrates are crucial for manufacturing laser gyroscope systems. This paper presents a prototype designed to meet the requirements for the reflection and transmission of laser gyroscope mirror substrates. The prototype featured two measurement channels (bright field and dark field) and could detect defects on patterned and unpatterned surfaces. Key components were simulated using Ansys software, (Ansys Workbench 2022 R1)which showed a maximum static deformation of 4.65 μm, a resonant frequency of at least around 230 Hz, and a maximum stress of 9.86 MPa under transportation conditions (GJB150.16A-2009). These results confirm the prototype's stability for optical performance testing and structural design. The experimental testing on laser gyroscope reflector substrates and USAF 1951 plates demonstrated that the prototype effectively detected defects on reflection and transmission surfaces, with a detection resolution that exceeded 170 nm, which met the design requirements.
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http://dx.doi.org/10.3390/mi15121498 | DOI Listing |
Micromachines (Basel)
December 2024
University of Science and Technology of China, Hefei 230026, China.
Defect detection and classification in super-high reflector mirrors and their substrates are crucial for manufacturing laser gyroscope systems. This paper presents a prototype designed to meet the requirements for the reflection and transmission of laser gyroscope mirror substrates. The prototype featured two measurement channels (bright field and dark field) and could detect defects on patterned and unpatterned surfaces.
View Article and Find Full Text PDFFront Oral Health
December 2024
Department of Oral Medicine and Radiology, Panineeya Dental College, Hyderabad, India.
Background: Intraoral radiography remains the most widely employed dental radiographic technique for producing geometrically accurate images with minimal distortion and magnification. Despite its common use in the dental office, incorrect projection geometry can be challenging leading to image distortions. To mitigate these inaccuracies specific radiographic landmarks on the face are utilized during periapical radiography.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
December 2024
4D Molecular Therapeutics, Emeryville, California, United States.
Purpose: Intravitreal delivery of therapeutic transgenes to the retina via engineered viral vectors can provide sustained local concentrations of therapeutic proteins and thus potentially reduce the treatment burden and improve long-term vision outcomes for patients with neovascular (wet) age-related macular degeneration (AMD), diabetic macular edema (DME), and diabetic retinopathy.
Methods: We performed directed evolution in nonhuman primates (NHP) to invent an adeno-associated viral (AAV) variant (R100) with the capacity to cross vitreoretinal barriers and transduce all regions and layers of the retina following intravitreal injection. We then engineered 4D-150, an R100-based genetic medicine carrying 2 therapeutic transgenes: a codon-optimized sequence encoding aflibercept, a recombinant protein that inhibits VEGF-A, VEGF-B, and PlGF, and a microRNA sequence that inhibits expression of VEGF-C.
Micromachines (Basel)
November 2024
School of Electrical Engineering, University of South China, Hengyang 421001, China.
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