A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Andrews (Haw.) Improves Losartan's Antihypertensive Activity. | LitMetric

Background: Cardiovascular diseases constitute one of the leading causes of morbidity and mortality worldwide. Herbal medicines represent viable alternatives to the synthetic drugs currently employed in the control of hypertension. This study aimed to isolate and identify the chemical markers of and to investigate the antihypertensive and anti-matrix metalloproteinase (MMP2) activities of an aqueous extract of the leaves.

Methods: The main constituents of the aqueous extract of were separated by ultra-performance liquid chromatography-mass spectrometry, and their presence was identified by NMR spectroscopy. Renovascular hypertension was induced in male Wistar rats using the two-kidney one-clip method (HTN groups), while control animals (Sham groups) were submitted to Sham surgery. Six groups of 10 animals each were treated daily for eight weeks as follows: Sham 1 (carrier), Sham 2 ( extract), HTN.1 (carrier), HTN.2 ( extract), HTN 3 (losartan), and HTN 4 ( extract with losartan).

Results: The main compounds of the extract were patuletin 3--(4″--acetyl-α-L-rhamnopyranosyl)-7--(3‴--acetyl-α-L-rhamnopyranoside) (), patuletin 3--α-L-rhamnopyranosyl-7--L-rhamnopyranoside (), and -caffeoyl-malic acid (), with compounds and being chemical markers of the species. Significant reductions ( < 0.05) in systolic blood pressure and MMP2 (72kDa isoform) activity were observed in the HTN 4 group.

Conclusions: The association of extract and losartan presented in vivo effects against hypertension.

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules29246010DOI Listing

Publication Analysis

Top Keywords

chemical markers
8
aqueous extract
8
extract
7
andrews haw
4
haw improves
4
improves losartan's
4
losartan's antihypertensive
4
antihypertensive activity
4
activity background
4
background cardiovascular
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!