(1) Background: Alkasite is a novel restorative material that has attracted interest in recent years because of its distinctive characteristics, including its high translucency and excellent biocompatibility. It is comparable to glass ionomer cement (GIC) and resin-modified glass ionomer cement (RMGIC) due to its fluoride-release ability and usage in esthetically concerned areas. This study aimed to assess the shear bond strength (SBS) of Alkasite restorative material in comparison with GIC and RMGIC (2) Methods: The study sample included 120 extracted sound primary molars and was randomly split into three groups, including group 1: RMGIC; group 2: Alkasite; and group 3: GIC. Each group was then sub-grouped into immediate and delayed loading. SBS was measured for each group using a universal testing machine. One-way analysis of variance with Tukey's post hoc test and an independent t-test were used for statistical analyses (3) Results: The immediate SBS was higher in Alkasite, followed by RMGIC and GIC, with means of 10.84 ± 1.96, 10.64 ± 1.74, and 6.09 ± 1.75, respectively. However, there was no significant difference between Alkasite and RMGIC ( = 0.94), whereas RMGIC and Alkasite showed significantly higher values than GIC, with < 0.0001. Regarding delayed SBS, no significant difference was noted between Alkasite and RMGIC ( = 0.14), whereas both showed significantly higher values than GIC, with mean values of 6.30 ± 1.44, 5.556 ± 1.38, and 3.29 ± 0.61, respectively ( < 0.0001). (4) Conclusions: Our findings show that RMGIC and Alkasite have comparable outcomes to each other and better outcomes when compared with conventional GIC.

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