Effects of High-Intensity Interval Training on Blood Pressure Levels in Hypertensive Patients: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Objective: This systematic review and meta-analysis aimed to (I) evaluate the evidence on the effects of high-intensity interval training (HIIT) on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in hypertensive patients; (II) determine whether HIIT impacts SBP and DBP differently; and (III) assess the clinical relevance of these effects.

Methods: A comprehensive search was conducted across multiple electronic databases, resulting in the inclusion of seven randomized clinical trials in the meta-analysis. The outcomes were analyzed using random-effects models to compute mean differences (MD) and standardized mean differences (SMD) for SBP and DBP.

Results: A small reduction in SBP was observed with HIIT interventions (MD -3.00; 95% CI -4.61 to -1.39; < 0.0001; SMD -0.28; 95% CI -0.42 to -0.13; = 0.0003). However, no statistically significant reductions were detected for DBP (MD -0.70; 95% CI -1.80 to 0.39; = 0.21; SMD -0.07; 95% CI -0.22 to 0.08; = 0.35). Despite demonstrating statistical significance for SBP, the effects did not reach clinical relevance.

Conclusions: HIIT interventions yield small reductions in SBP, with minimal impact on DBP. These findings suggest limited clinical relevance in the management of hypertension. Further randomized controlled trials are necessary to standardize HIIT protocols, with specific emphasis on intensity control and manipulation, to better understand their potential role in hypertensive populations.