Most existing methods for magnetic resonance imaging (MRI) reconstruction with deep learning use fully supervised training, which assumes that a fully sampled dataset with a high signal-to-noise ratio (SNR) is available for training. In many circumstances, however, such a dataset is highly impractical or even technically infeasible to acquire. Recently, a number of self-supervised methods for MRI reconstruction have been proposed, which use sub-sampled data only. However, the majority of such methods, such as Self-Supervised Learning via Data Undersampling (SSDU), are susceptible to reconstruction errors arising from noise in the measured data. In response, we propose Robust SSDU, which provably recovers clean images from noisy, sub-sampled training data by simultaneously estimating missing k-space samples and denoising the available samples. Robust SSDU trains the reconstruction network to map from a further noisy and sub-sampled version of the data to the original, singly noisy, and sub-sampled data and applies an additive Noisier2Noise correction term upon inference. We also present a related method, Noiser2Full, that recovers clean images when noisy, fully sampled data are available for training. Both proposed methods are applicable to any network architecture, are straightforward to implement, and have a similar computational cost to standard training. We evaluate our methods on the multi-coil fastMRI brain dataset with novel denoising-specific architecture and find that it performs competitively with a benchmark trained on clean, fully sampled data.
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http://dx.doi.org/10.3390/bioengineering11121305 | DOI Listing |
Bioengineering (Basel)
December 2024
Department of Medical Biophysics, University of Toronto, Toronto, ON M4N 3M5, Canada.
Most existing methods for magnetic resonance imaging (MRI) reconstruction with deep learning use fully supervised training, which assumes that a fully sampled dataset with a high signal-to-noise ratio (SNR) is available for training. In many circumstances, however, such a dataset is highly impractical or even technically infeasible to acquire. Recently, a number of self-supervised methods for MRI reconstruction have been proposed, which use sub-sampled data only.
View Article and Find Full Text PDFPhys Med Biol
August 2018
Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States of America.
Small animal positron emission tomography (PET) imaging often requires high resolution (∼few hundred microns) to enable accurate quantitation in small structures such as animal brains. Recently, we have developed a prototype ultrahigh resolution depth-of-interaction (DOI) PET system that uses CdZnTe detectors with a detector pixel size of 350 μm and eight DOI layers with a 250 μm depth resolution. Due to the large number of line-of-response (LOR) combinations of DOIs, the system matrix for reconstruction is 64 times larger than that without DOI.
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