DeSPPNet: A Multiscale Deep Learning Model for Cardiac Segmentation.

Background: Cardiac magnetic resonance imaging (MRI) plays a crucial role in monitoring disease progression and evaluating the effectiveness of treatment interventions. Cardiac MRI allows medical practitioners to assess cardiac function accurately by providing comprehensive and quantitative information about the structure and function, hence making it an indispensable tool for monitoring the disease and treatment response. Deep learning-based segmentation enables the precise delineation of cardiac structures including the myocardium, right ventricle, and left ventricle. The accurate segmentation of these structures helps in the diagnosis of heart failure, cardiac functional response to therapies, and understanding the state of the heart functions after treatment.

Objectives: The objective of this study is to develop a multiscale deep learning model to segment cardiac organs based on MRI imaging data. Good segmentation performance is difficult to achieve due to the complex nature of the cardiac structure, which includes a variety of chambers, arteries, and tissues. Furthermore, the human heart is also constantly beating, leading to motion artifacts that reduce image clarity and consistency. As a result, a multiscale method is explored to overcome various challenges in segmenting cardiac MRI images.

Methods: This paper proposes DeSPPNet, a multiscale-based deep learning network. Its foundation follows encoder-decoder pair architecture that utilizes the Spatial Pyramid Pooling (SPP) layer to improve the performance of cardiac semantic segmentation. The SPP layer is designed to pool features from densely convolutional layers at different scales or sizes, which will be combined to maintain a set of spatial information. By processing features at different spatial resolutions, the multiscale densely connected layer in the form of the Pyramid Pooling Dense Module (PPDM) helps the network to capture both local and global context, preserving finer details of the cardiac structure while also capturing the broader context required to accurately segment larger cardiac structures. The PPDM is incorporated into the deeper layer of the encoder section of the deep learning network to allow it to recognize complex semantic features.

Results: An analysis of multiple PPDM placement scenarios and structural variations revealed that the 3-path PPDM, positioned at the encoder layer 5, yielded optimal segmentation performance, achieving dice, intersection over union (IoU), and accuracy scores of 0.859, 0.800, and 0.993, respectively.

Conclusions: Different PPDM configurations produce a different effect on the network; as such, a shallower layer placement, like encoder layer 4, retains more spatial data that need more parallel paths to gather the optimal set of multiscale features. In contrast, deeper layers contain more informative features but at a lower spatial resolution, which reduces the number of parallel paths required to provide optimal multiscale context.