Comparative Genome Analysis of Canine Isolates.

: The One Health approach is crucial for managing and controlling the spread of antimicrobial resistance. is a recently identified bacterial species that seems to be a component of the oral microbiota of dogs; however, its pathogenic nature is questionable. : In this study, the antibacterial susceptibility of isolates was determined using the disk diffusion and broth microdilution methods. Genome-wide comparative analyses were performed to identify the genetic factors driving virulence and antimicrobial drug resistance (e.g., virulence factors, antimicrobial resistance genes (ARGs) and prophage-related sequences). : Most of the isolates lacked virulence-associated genes. is likely resistant to clindamycin, lincomycin and neomycin, but susceptible to penicillin, erythromycin and enrofloxacin. Antimicrobial resistance genes were not found in the genomes, but prophage-related sequences were identified, suggesting its potential in the transfer of genes associated with drug resistance between bacteria in the oral microbiome. : is presumably a commensal organism with low virulence potential, as evidenced by the absence of virulence-associated genes. As can colonize a wide range of hosts, including humans, further investigation with a greater number of isolates is needed to better understand the role of in disease development and the spread of drug resistance.