Background: Lung cancer is an oncological threat worldwide, including in Italy. New organizational approaches based on a network of cancer centers and multidisciplinary and technological innovation are required. The experience in the Liguria region, in northwestern Italy, in the management of lung cancer is presented with a focus on the organizational model.

Methods: A retrospective observational analysis was conducted for the period from January 2019 to December 2023 using administrative regional data.

Results: Of the total surgery treatments in Liguria, most were carried out at the IRCCS San Martino (about 47%), which is the hub's center. Most cases involved males aged ≥65 years ( < 0.001). Passive mobility showed a decrease in recent years. Considering the type of access to clinical structures, almost all that were finalized to receive chemotherapy were from the day hospital regimen (99%).

Conclusion: A comprehensive approach must be carried out for cancer patients to maintain high levels of care quality. In this challenging context, the Liguria region has implemented new organizational approaches based on the networking of cancer centers and multidisciplinary and technological innovation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675364PMC
http://dx.doi.org/10.3390/healthcare12242556DOI Listing

Publication Analysis

Top Keywords

lung cancer
12
management lung
8
organizational approaches
8
approaches based
8
cancer centers
8
centers multidisciplinary
8
multidisciplinary technological
8
technological innovation
8
liguria region
8
cancer
6

Similar Publications

Background: Immuno-chemotherapy has demonstrated significant anti-tumor effects in patients with resectable nonsmall cell lung cancer (NSCLC). Additionally, for patients initially diagnosed with unresectable stage III NSCLC, induction immuno-chemotherapy may achieve tumor downstaging, enabling conversion to resectable disease allowing for by R0 resection. This study aimed to assess the effectiveness and safety of induction immuno-chemotherapy followed by conversion surgery in unresectable stage III NSCLC.

View Article and Find Full Text PDF

Phase I Clinical Trial of Autologous Hematopoietic Stem Cell Transplantation-Supported Dose-Intensified Chemotherapy With Adebrelimab as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer.

Clin Lung Cancer

December 2024

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:

Background: Small cell lung cancer (SCLC) is initially highly sensitive to chemotherapy, which often leads to significant tumor reduction. However, the majority of patients eventually develop resistance, and the disease is further complicated by its "cold" tumor microenvironment, characterized by low tumor immunogenicity and limited CD8+ T cell infiltration. These factors contribute to the poor response to immunotherapy in many cases of extensive-stage SCLC (ES-SCLC).

View Article and Find Full Text PDF

Malignant peripheral nerve sheath tumours (MPNSTs) are aggressive sarcomas that occur rarely in the cervix. Considering the varied clinical features and the absence of a pathognomonic immunohistochemical marker, it is always challenging to diagnose these tumours. Treatment has not been standardised as yet, but a combination of surgery, radiotherapy and chemotherapy is used to treat MPNSTs of the cervix.

View Article and Find Full Text PDF

Background: More efficient therapeutic options for non-small cell lung cancer (NSCLC) are needed as the survival at 5 years of metastatic disease is near zero. In this regard, we used a preclinical model of metastatic lung adenocarcinoma (SV2-OVA) to assess the safety and efficacy of novel radio-immunotherapy combining hypofractionated radiotherapy (HRT) with muPD1-IL2v immunocytokine and muFAP-CD40 bispecific antibody.

Methods: We evaluated the changes in the lung immune microenvironment at multiple timepoints following combination therapies and investigated their underlying antitumor mechanisms.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!