Coronary artery calcium (CAC) score is a neglected biomarker that can be derived from non-cardiac chest computed tomography scan and represents a surrogate for atherosclerosis. We created a simulation model using different CAC score values in the MESA coronary artery risk score in a population derived from the Fourier Trial. CAC score could modulate the sample sizes of cardiovascular trials in primary and secondary prevention and offer new primary prevention treatments to high-risk subjects with reasonable numbers needed to treat comparable to secondary prevention trials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jjcc.2024.12.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Novel Approach for the Treatment of Subclavian Steal Syndrome in a Patient Undergoing Coronary Artery Bypass Grafting.
Balkan Med J
January 2025
Clinic of Cardiovascular Surgery, VM Medicalpark Bursa Hospital, Bursa, Türkiye.
DCA-YOLOv8: A Novel Framework Combined with AICI Loss Function for Coronary Artery Stenosis Detection.
Sensors (Basel)
December 2024
School of Information Engineering and Automation, Kunming University of Science and Technology, Kunming 650500, China.
Coronary artery stenosis detection remains a challenging task due to the complex vascular structure, poor quality of imaging pictures, poor vessel contouring caused by breathing artifacts and stenotic lesions that often appear in a small region of the image. In order to improve the accuracy and efficiency of detection, a new deep-learning technique based on a coronary artery stenosis detection framework (DCA-YOLOv8) is proposed in this paper. The framework consists of a histogram equalization and canny edge detection preprocessing (HEC) enhancement module, a double coordinate attention (DCA) feature extraction module and an output module that combines a newly designed loss function, named adaptive inner-CIoU (AICI).
View Article and Find Full Text PDFWnt Signaling Inhibitors as Therapeutic Approach in Ischemic Heart Disease.
Molecules
December 2024
Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia.
Wnt (wingless-type MMTV integration site family) signaling is an evolutionary conserved system highly active during embryogenesis, but in adult hearts has low activities under normal conditions. It is essential for a variety of physiological processes including stem cell regeneration, proliferation, migration, cell polarity, and morphogenesis, thereby ensuring homeostasis and regeneration of cardiac tissue. Its dysregulation and excessive activation during pathological conditions leads to morphological and functional changes in the heart resulting in impaired myocardial regeneration under pathological conditions such as myocardial infarction, heart failure, and coronary artery disease.
View Article and Find Full Text PDFEndothelial Dysfunction: Molecular Mechanisms and Therapeutic Strategies in Kawasaki Disease.
Int J Mol Sci
December 2024
Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy.
The endothelium plays a key role in regulating vascular homeostasis by responding to a large spectrum of chemical and physical stimuli. Vasculitis is a group of inflammatory conditions affecting the vascular bed, and it is known that they are strongly linked to endothelial dysfunction (ED). Kawasaki disease (KD) is one childhood systemic vasculitis, and it represents the leading cause of acquired cardiac disease in children due to coronary damage and subsequent cardiovascular (CV) morbidity and mortality.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!