Background: Sinonasal malignancies, in which squamous cell carcinomas are the most common are rare and difficult to treat given the location and anatomical structures involved. Sinonasal malignancies often present late due to non-specific and benign symptoms. Partial resections are often associated with poorer outcomes [1]. Combined approaches can improve extent of resection of tumour involving sinonasal tumours with significant intracranial extension and allows skull base reconstructions from above with pericranium and below with a nasal septal flap [2]. Complete resection has been shown to improve metastatic burden and improve survival [3]. Up to 85 % local control with mean follow up of 37 months have been shown with patient's undergoing either endoscopic or combined endoscopic with open cranial resection techniques [4].
Case Description: We present a case a sinonasal carcinoma crossing multiple compartments requiring a multidisciplinary approach for safe, expeditious and total resection via a combined endoscopic and open approach.
Conclusion: Endoscopic Assisted Craniofacial resection can be adjuncted with endo-orbital techniques establishing the lateral border of the resection whilst protecting the orbital contents as well as facilitating resection margins.
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http://dx.doi.org/10.1016/j.jocn.2024.110972 | DOI Listing |
J Thorac Oncol
January 2025
Department of Cardiothoracic Surgery, New York University Langone Health, New York, New York. Electronic address:
Introduction: The phase 3 randomized controlled trial of extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (PM) (MARS2) reported "extended pleurectomy decortication was associated with worse survival to 2 years, and more serious adverse events for individuals with resectable PM, compared with chemotherapy alone." These results have led to considerable discourse regarding the future role of surgery for PM, and there has not been unanimity in the mesothelioma surgical community regarding the trial interpretation. This "perspective" evaluates MARS2 using internationally renowned PM experts who either agreed with the trial interpretation or who found issues with its conduct which may have influenced the results.
View Article and Find Full Text PDFAfr J Reprod Health
December 2024
Department of Medical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
This was an original article, and the objective of this study was to investigate the effects of bipolar transurethral plasma kinetic prostatectomy (TUPKP) on urodynamics and sexual function in benign prostatic hyperplasia (BPH) patients. One hundred and four BPH patients were divided into a control group and an intervention group. The control group received transurethral resection of prostate, while the intervention group received TUKEP.
View Article and Find Full Text PDFPharmaceuticals (Basel)
November 2024
Department of Nuclear Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.
: Dual-modality probes, combining positron emission tomography (PET) with fluorescence imaging (FI) capabilities in a single molecule, are of high relevance for the accurate staging and guided resection of tumours. We herein present a pair of candidates targeting the cholecystokinin-2 receptor (CCK2R), namely [Ga]Ga-CyTMG and [Ga]Ga-CyFMG. In these probes, the SulfoCy5.
View Article and Find Full Text PDFMolecules
December 2024
Department of Chemistry, RCSI, University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin 2, D02 YN77 Dublin, Ireland.
The term "fluorescence" was first proposed nearly two centuries ago, yet its application in clinical medicine has a relatively brief history coming to the fore in the past decade. Nowadays, as fluorescence is gradually expanding into more medical applications, fluorescence image-guided surgery has become the new arena for this technology. It allows surgical teams to real-time visualize target tissues or anatomies intraoperatively to increase the precision of resection or preserve vital structures during open or laparoscopic surgeries.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
The James Comprehensive Cancer Center, Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Retroperitoneal liposarcoma (RPLPS) is one of the most common histologic subtypes of soft tissue sarcoma (STS). Complete surgical resection remains the mainstay treatment, while the high rate of locoregional recurrence constitutes the predominant cause of mortality. Well-differentiated (WDLPS) and dedifferentiated (DDLPS) liposarcoma are the most frequent subtypes of RPLPS and present amplified MDM2 gene as a hallmark.
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