Purpose: Low density of electroencephalogram alpha band power was reported to be associated with perioperative cognitive dysfunction. Few studies have conducted to explore the effects of remimazolam on intraoperative frontal alpha band power spectrum density in older adults. Here, we aimed to explore the impact of remimazolam on intraoperative frontal brain wave alpha band activity and postoperative cognitive function in older adults undergoing lower extremity fractures surgeries.
Methods: Patients undergoing elective general anesthesia for lower extremity fracture surgery were randomly allocated to remimazolam group (Group R) and midazolam group (Group M). Group R was induced with remimazolam bolus 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg·h for general anesthesia. Group M was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 mL·kg·h. The rest anesthesia protocol was the same for both groups. Electroencephalogram data was recorded before anesthesia induction till the end of surgery. Cognitive function was assessed preoperatively, and at the first, third, fifth, and seventh day postoperatively.
Results: Compared with Group M, Group R had significantly higher intraoperative power spectral density of the frontal alpha band ( < 0.001), and significantly lower incidence of postoperative cognitive dysfunction at T and T (P = 0.031 and P = 0.017, respectively).
Conclusion: Remimazolam can increase frontal brain wave alpha band power spectrum density and improve postoperative cognitive function in older adults undergoing lower extremity fractures surgeries.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700878 | PMC |
| http://dx.doi.org/10.2147/CIA.S496437 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Photocatalytic degradation of NO by MnO catalyst: The decisive relationship between crystal phase, morphology and activity.
J Hazard Mater
January 2025
College of Carbon Neutrality Future Technology, Sichuan University, Chengdu, Sichuan 610065, China; National Engineering Research Center for Flue Gas Desulfurization, Chengdu, Sichuan 610065, China; Industrial Technology Research Institute, Sichuan University, Yibin 644004, China. Electronic address:
This study investigates the critical relationship between the crystal phase, morphology, and photocatalytic activity of MnO. The δ-MnO nanosheets, characterized by multiple exposed crystal planes forming junctions, exhibit optimized optical and electrical properties. Oxygen vacancy concentrations were observed in the order δ-MnO > γ-MnO > α-MnO, with corresponding increases in band gap width from 1.
View Article and Find Full Text PDFLuteolin ameliorates rat model of metabolic syndrome-induced cardiac injury by apoptosis suppression and autophagy promotion via NR4A2/p53 regulation.
BMC Complement Med Ther
January 2025
Department of Cardiovascular Medicine, First Hospital of Northwest University, Xi'an, 710043, China.
Background: Reduced cardiac autophagy, inflammation, and apoptosis contribute to cardiovascular complications caused by metabolic syndrome (MetS). It is documented that the nuclear receptor 4A2 (NR4A2) could modulate autophagy and apoptosis in cardiac complications. The aim of this investigation was to assess the therapeutic potential of luteolin, with documented beneficial properties, against MetS-associated cardiac injury.
View Article and Find Full Text PDFPreparation of protein and its preventive effect on nonalcoholic fatty liver disease in mice.
Food Funct
January 2025
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungi Resources and Utilization (South), Ministry of Agriculture, 201403, China.
is a valuable edible fungus with multidimensional bioactivities; however, research on protein and its beneficial effects on nonalcoholic fatty liver disease (NAFLD) have been limited. In this study, protein (MEP) with 80.59% protein content was prepared, isolated, and characterized by the complete amino acid composition.
View Article and Find Full Text PDFAlterations in resting-state EEG functional connectivity in patients with major depressive disorder receiving electroconvulsive therapy: A systematic review.
Neurosci Biobehav Rev
January 2025
Experimental Cognitive and Clinical Affective Neuroscience (ECAN) Laboratory, Department of Clinical Research (DKF), University of Basel, Switzerland; Center for Affective, Stress and Sleep Disorders, University Psychiatric Clinics (UPK) Basel, Switzerland.
Electroconvulsive therapy (ECT) is highly efficacious for the treatment of major depressive disorder (MDD), but its mechanisms still require clarification. Even though depression is associated with alterations in functional connectivity (FC), EEG studies investigating effects of ECT on FC have not been systematically reviewed. Understanding these effects may help to identify the role of functional brain circuits in depression and its remission.
View Article and Find Full Text PDFInterpersonal space is regulated carefully and updated dynamically during social interactions to maintain comfort. We investigated the naturalistic processing of interpersonal distance in real time and space using a powerful implicit neurophysiological measure of attentional engagement. In a sample of 37 young adults recruited at a UK university, we found greater EEG alpha band suppression when a person occupies or moves into near personal space than for a person occupying or moving into public space.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!