Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Background: Chondrosarcoma is the second most common bone malignancy. Chondrosarcoma is considered a surgical disease, and the role of surgical margin is important since local recurrence is known to decrease survival. The aim of this study was to investigate the timing of local recurrence and the size of local recurrence in post local recurrence survival in chondrosarcoma.
Methods: We reviewed data from one international tertiary sarcoma hospital. Between 1990 and 2022, 911 patients with chondrosarcoma of the pelvis and extremities were identified and 161 (18 %) had a local recurrence. Competing risk analysis was used to identify the timing and size of local recurrence in post local recurrence survival in different grades.
Results: Increasing size of local recurrence was a statistically significant negative factor in grade 2 chondrosarcoma patients. The timing of local recurrence was not significant for post local recurrence survival. Only 7 % of the local recurrences in high grade tumours were detected after five years after index surgery.
Conclusion: In this study we have shown that the size of local recurrence emerges as a significant factor in grade 2 tumours. Timing of local recurrence does not significantly predict the post local recurrence survival. Moreover, only 7 % of local recurrences are detected after five years in high grade tumours. Therefore, we recommend that active surveillance efforts be particularly focused on grade 2 chondrosarcomas during the initial five years after index surgery.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700281 | PMC |
http://dx.doi.org/10.1016/j.jcot.2024.102866 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!