Background: The aim of this prospective cohort study is to build evidence on transmission dynamics and risk factors for infections in cholera patient households.
Methods: Household contacts of cholera patients were observed for 1-month after the index cholera patient was admitted to a health facility for stool, serum, and water collection in urban Bukavu in South Kivu, Democratic Republic of the Congo. A infection was defined as a bacterial culture positive result during the 1-month surveillance period and/or a four-fold rise in a O1 serological antibody from baseline to the 1-month follow-up.
Results: Twenty-seven percent of contacts (134 of 491) of cholera patients had a infection during the surveillance period. Twelve percent (9 of 77) of cholera patient households had a stored water sample with by bacterial culture, and 7% (5 of 70) had a water source sample with . Significant risk factors for symptomatic infections among contacts were stored food left uncovered (Odds Ratio (OR): 2.39, 95% Confidence Interval (CI): 1.13, 5.05) and younger age (children <5 years) (OR: 2.09, 95% CI: 1.12, 3.90), and a drinking water source with >1 colony forming unit . / 100mL (OR: 3.59, 95% CI: 1.46, 8.84) for infections.
Conclusions: The findings indicate a high risk of cholera among contacts of cholera patients in this urban cholera endemic setting, and the need for targeted water treatment and hygiene interventions to prevent household transmission of .
Summary: In this prospective cohort study in the Democratic Republic of the Congo, the majority of cholera patient households had multiple infected household members and both source water and stored drinking water samples had .
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| http://dx.doi.org/10.1101/2024.12.16.24318937 | DOI Listing |
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