Therapeutic Efficacy of Re-Lin-Qing Granules in Treating Type 2 Diabetes Mellitus Complicated with Urinary Tract Infection: A Retrospective Study.

Purpose: Urinary tract infections (UTIs) frequently occur in patients with type 2 diabetes mellitus (T2DM), presenting a complex pathogenesis that significantly impairs patient quality of life. Despite the availability of various clinical treatments, challenges remain regarding their efficacy and safety. Therefore, this retrospective study aimed to observe the therapeutic effects of Re-Lin-Qing granules in treating T2DM complicated by UTIs, aiming to provide more scientifically validated and effective treatment options for clinical practice.

Methods: A retrospective analysis was conducted on 115 patients with T2DM complicated by UTIs to compare the efficacy of routine treatment alone (routine group, n = 56) vs. routine treatment combined with Re-Lin-Qing granules (combined treatment group, n = 59). Baseline characteristics, UTI parameters, inflammatory marker levels, and adverse events were evaluated.

Results: The combined treatment group demonstrated lower leukocyte counts in urine (120.28 ± 30.14 cells/µL vs. 100.23 ± 25.16 cells/µL, < 0.001), a reduced percentage of positive nitrite in urine (39.29% vs. 20.34%, = 0.043), and a lower rate of positive urine cultures (55.36% vs. 33.90%, = 0.033) for bacteria compared to the routine group. Additionally, inflammatory marker levels, including C-reactive protein (14.68 ± 1.25 vs. 14.15 ± 1.09, = 0.017) and interleukin-6 (4.29 ± 0.81 vs. 3.97 ± 0.75, = 0.028), were significantly lower in the combined treatment group. The occurrence of adverse events did not differ significantly between the two groups ( > 0.05).

Conclusions: The study provides evidence supporting the potential therapeutic benefits of Re-Lin-Qing granules as an adjunct therapy for T2DM complicated by UTIs. The findings indicate improvements in UTI parameters and inflammatory markers in the combined treatment group, highlighting the potential clinical benefits of incorporating Re-Lin-Qing granules into managing these comorbid conditions.