Background: According to the World Health Organization (WHO), there were 1.19 million road traffic accident (RTA)-related deaths in 2021, with a significantly higher death rate in developing countries than in developed countries.
Objective: To assess the distribution of causes of death and associated organ injuries in RTA-related fatalities.
Methods: This retrospective cross-sectional study was conducted at the Department of Forensic Medicine and Toxicology of Saint Paul's Hospital Millennium Medical College (SPHMMC), Addis Ababa, Ethiopia. This study included 207 autopsies of RTA-related deaths.
Results: Among the 198 victims, 70.7 percent were males and 29.3 percent were females, with a mean age of 36.65 (years). The leading causes of death were craniocerebral injury (36.9%) and polytrauma (14.6%). The majority (49%) died in the prehospital setting, 37.9% at the hospital, and 5.6% at home. Pedestrians were the most affected (71%), followed by passengers (16%). Urban areas had a higher incidence of accidents (58.1%). All victims had soft tissue injuries, with 75.3% sustaining head injuries, 58.6% sustaining musculoskeletal injuries, and 51% sustaining thoracic injuries.
Conclusion: Addressing RTA-related deaths requires a multifaceted approach involving various stakeholders. Building a prehospital emergency service, providing first aid training, and continuous professional development training to health professionals are also important.
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http://dx.doi.org/10.1186/s12889-024-21220-2 | DOI Listing |
Biochim Biophys Acta Mol Cell Res
January 2025
Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/4 EAST, 8010 Graz, Austria; BioTechMed, Graz, Austria. Electronic address:
The uptake of Ca by mitochondria is an important and tightly controlled process in various tissues. Even small changes in the key proteins involved in this process can lead to significant cellular dysfunction and, ultimately, cell death. In this study, we used stimulated emission depletion (STED) microscopy and developed an unbiased approach to monitor the sub-mitochondrial distribution and dynamics of the mitochondrial calcium uniporter (MCU) and mitochondrial calcium uptake 1 (MICU1) under resting and stimulated conditions.
View Article and Find Full Text PDFJFMS Open Rep
January 2025
NEIKER-BRTA (Instituto Vasco de Investigación y Desarrollo Agrario - Basque Research and Technology Alliance), Derio, Bizkaia, Spain.
Case Summary: is a globally distributed apicomplexan protozoan infecting all warm-blooded animals. Cats are the definitive host, susceptible to clinical disease. In Spain, studies have shown the widespread presence of IgG antibodies in cats but there are no published data on clinical toxoplasmosis in cats from Spain.
View Article and Find Full Text PDFJ Res Med Sci
November 2024
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: In the present study, we aimed to evaluate the effects of medroxyprogesterone on hospital short clinical outcomes and ABG parameters in patients with chronic obstructive pulmonary disease (COPD) exacerbation under treatments with noninvasive ventilation (NIV) treated with progesterone 15 mg in comparison with placebo.
Materials And Methods: This is a double-blinded clinical trial that was performed in 2020-2021 in Isfahan, Iran, on 60 patients with COPD exacerbation that require NIV. All patients received short-acting beta-agonists, short-acting anticholinergics, systemic corticosteroids, and NIV.
Obesity, insulin resistance, and a host of environmental and genetic factors can drive hyperglycemia, causing β-cells to compensate by increasing insulin production and secretion. In type 2 diabetes (T2D), β-cells under these conditions eventually fail. Rare β-cell diseases like congenital hyperinsulinism (HI) also cause inappropriate insulin secretion, and some HI patients develop diabetes.
View Article and Find Full Text PDFEpidemiol Infect
January 2025
School of Life Sciences, Faculty of Natural Sciences, Keele University, Keele, Staffordshire, UK.
In 2023, Bangladesh experienced its largest and deadliest outbreak of the Dengue virus (DENV), reporting the highest-ever recorded annual cases and deaths. Historically, most of the cases were recorded in the capital city, Dhaka. We aimed to characterize the geographical transmission of DENV in Bangladesh.
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