Cerebral palsy (CP) is the most common neuromuscular disorder in children with no effective therapeutic methods. To examine CP, a large variety of methods and animal models was developed, the most popular are the hypoxic-ischemic (HI) injury and/or LPS injection in mice. In the presented work, HI and LPS were applied on the postnatal day 9 to humanized immunodeficiency mouse pups, thereupon 3 behavioral tests were performed in 8 weeks later. Both HI and LPS caused significant behavioral deficits assessed in the Rotarod test. In gait dynamics and open-field tests, HI and LPS caused significant behavioral deficits reported by some parameters, and the effect of HI was more severe. Additionally, HI and LPS produced the different effects on gait dynamics of the fore and hind paws. Thus, both HI and LPS induced the behavioral disorders in mice, but HI was more suitable for the development of humanized immunodeficiency mouse model of CP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-025-06320-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Balance assessment with smartphone devices in para-footballers with cerebral palsy.
J Sci Med Sport
December 2024
Department of Sport Sciences, Miguel Hernández University of Elche, Spain.
Objectives: To explore whether the mean lumbar acceleration is a feasible tool for determining minimum eligibility criteria to compete in cerebral palsy football, differentiating between new sports classes, and to assess the effect of foot contacts on balance evaluation and class distinction.
Design: Cross-sectional study.
Methods: A total of 146 male cerebral palsy footballers classified into FT1 (n=34), FT2 (n=87), and FT3 (n=25), alongside 12 non-impaired athletes as a control group, participated.
Construction and Behavioral Comparison of Two Mouse Models of Cerebral Palsy.
Bull Exp Biol Med
January 2025
Institute of Medical Imaging, Guangzhou Panyu Central Hospital, Guangzhou, China.
Cerebral palsy (CP) is the most common neuromuscular disorder in children with no effective therapeutic methods. To examine CP, a large variety of methods and animal models was developed, the most popular are the hypoxic-ischemic (HI) injury and/or LPS injection in mice. In the presented work, HI and LPS were applied on the postnatal day 9 to humanized immunodeficiency mouse pups, thereupon 3 behavioral tests were performed in 8 weeks later.
View Article and Find Full Text PDFFrequency and Distribution of Perinatal Arterial Ischemic Stroke in a Cohort of Patients With Cerebral Palsy Using Delayed MRI.
J Comput Assist Tomogr
November 2024
Graduate MBA Program, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Cambridge, United Kingdom.
Purpose: This study examined the occurrence and MRI characteristics of perinatal arterial ischemic stroke (PAIS) in children with cerebral palsy (CP) and suspected term hypoxic-ischemic injury (HII).
Methods: A retrospective review of brain MRI scans was conducted on children with CP and suspected term HII in South Africa.
Results: Out of 1620 children with CP included in the study, 15 (0.
Postanesthesia Sling Lift Transfer and Upright Extubation of an Adult Secured in a Motorized Wheelchair: A Case Report.
A A Pract
January 2025
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
This case report describes a 29-year-old patient with cerebral palsy whose mother, for safety reasons, requested that before extubation in the postanesthesia care unit, her son be transferred from the padded stretcher to his personal motorized wheelchair. Using a sling lift, we safely transferred the anesthetized, intubated patient from a supine position to an upright sitting position. Although sling lifts are often used in critical care and rehabilitation environments, use in the perioperative space is rare.
View Article and Find Full Text PDFInvestigating a caregiver-assisted social skills group programme for primary and early high school-aged children with acquired brain injury or cerebral palsy: protocol for a pilot mixed-methods, two-group randomised trial of PEERS Plus.
BMJ Open
January 2025
Queensland Cerebral Palsy and Rehabilitation Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Introduction: Reaching social milestones is an important goal of childhood. Children with acquired brain injury (ABI) and cerebral palsy (CP) frequently experience challenges with social functioning and participation. The Programme for the Education and Enrichment of Relational Skills (PEERS) is a group-based social skills programme for adolescents.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!