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BNT162b2 mRNA vaccine elicits robust virus-specific antibodies but poor cross-protective CD8 memory T cell responses in adolescents with type 1 diabetes.
J Microbiol Immunol Infect
January 2025
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan. Electronic address:
Background: COVID-19 mRNA vaccines have demonstrated 95 % efficacy in the general population. However, their immunogenicity in adolescents with Type 1 Diabetes (T1D), who exhibit weaken immune responses, remains insufficiently explored.
Methods: Longitudinal analysis of innate immune responses following PRR-agonists and BNT162b2 vaccine stimulations, along with S-specific antibody responses, memory T cell recall responses, and RNA-sequencing were assessed in eight T1D adolescents and 16 healthy controls at six different timepoints.
Post-pandemic epidemiological trends of respiratory infectious diseases in Taiwan: A retrospective analysis.
J Microbiol Immunol Infect
December 2024
Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan. Electronic address:
Background: This study analyzed the epidemiological trends of three significant respiratory infectious diseases in Taiwan: invasive pneumococcal disease (IPD), influenza with severe complications, and tuberculosis during post-COVID-19 pandemic period.
Methods: We utilized data from Taiwan's Centers for Disease Control and Prevention (CDC) website and classified the COVID-19 prevention policies into three phases for the year 2021, 2022, and 2023. We then performed a statistical analysis of reported case numbers for the three respiratory diseases during the 3-year period using the Kruskal-Wallis test, followed by joinpoint regression model for the identification of seasonal distribution and variation.
Osteochondral lesions of the talus with small cysts may not affect the outcome of arthroscopic microfracture: A systematic review and meta-analysis.
Foot Ankle Surg
January 2025
Department of Orthopaedics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China. Electronic address:
Background: The optimal treatment of Osteochondral lesion of the talus (OLT) for subchondral bone cysts (SBCs) has not been finalized. The purpose of this systematic review and meta-analysis was to define whether OLT with small SBCs will affect the clinical outcomes of OLTs after arthroscopic microfracture.
Methods: We searched the Embase, Cochrane Library and PubMed databases up to May 13, 2024 for eligible comparative studies.
Generational Differences in Self-Esteem and Vocal Perception Among Brazilian Gay Men.
J Voice
January 2025
Speech-Language Pathology Department, Universidade Federal de São Paulo - UNIFESP, Rua Botucatu, 802 Vila Clementino, 04023-062, São Paulo, São Paulo, Brazil. Electronic address:
Introduction: Self-esteem and vocal perception are central aspects of identity and self-presentation, particularly within marginalized communities where voice and self-concept can be deeply intertwined with social acceptance and cultural dynamics. Among Brazilian gay men, generational differences in these areas may reflect broader social changes, shifts in stigma, and evolving notions of masculinity. This study aims to explore these differences, examining how self-esteem and self-assessed vocal descriptions vary across generations, thereby shedding light on specific needs and areas for potential support within these communities.
View Article and Find Full Text PDFSex Differences in Late-life Cognition: A Psychometric Network Analysis of Well-functioning Older Adults.
Am J Geriatr Psychiatry
December 2024
Department of Gerontology, Faculty of Social Welfare & Health Sciences, University of Haifa, 199 Aba Khoushy Ave, Haifa, 3498838, Israel. Electronic address:
Objective: Unidentified sex differences in old-age cognition may emerge in psychometric networks, which look beyond mean scores into the unique cognitive structure of males and females. Accordingly, this study aims to examine cognition in well-functioning older males and females with psychometric network analysis.
Methods: The current cohort (N = 2,802) of community-dwelling adults (≥65 years) was derived from the Advanced Cognitive Training for Independent and Vital Elderly study.
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