Compartment syndrome caused by Streptococcus pyogenes (Group A Streptococcus) has rarely been documented. We report the case of a 53-year-old male, hypertensive, who developed compartment syndrome and myositis in the right lower limb. The patient underwent emergency fasciotomies of the anterior, lateral, superficial posterior and deep posterior compartments of the leg and two subsequent surgical debridements, in addition to receiving antibiotic treatment and delayed closure of the fasciotomies with grafts. As sequelae, the patient experiences joint stiffness and hypoesthesia in the area of the external popliteal sciatic nerve. Early recognition of the issue, timely intervention, and postoperative follow-up were crucial elements.
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