Numerous studies indicate that Schisandra chinensis (Turcz.) Baill (SC) has anti-type 2 diabetes mellitus (T2DM) effects, and its processed products are commonly used in clinical practice. However, limited reports exist on the mechanisms of polysaccharides from its vinegar products and their role in T2DM. We purified a novel polysaccharide from vinegar-processed Schisandra chinensis (VSC) and used intestinal microbiota 16S rRNA analysis and metabolomics to study changes in T2DM mice after vinegar-processed Schisandra chinensis polysaccharide (VSP) intervention, aiming to elucidate how VSP alleviates T2DM. VSP has shown significant therapeutic effects in T2DM mice, which can regulate the imbalance of glucose and lipid metabolism, alleviate pancreatic and liver damage, restore the integrity of the intestinal barrier, and inhibit the inflammatory response. Serum metabolomics and microbiological analysis showed that VSP could significantly regulate 104 endogenous metabolites and rectify gut microbiota disorders in T2DM mice. Additionally, VSP enhanced the levels of short-chain fatty acids (SCFAs) and the expression of GPR41/43 in the colon of T2DM mice. Correlation analysis revealed significant correlations among specific gut microbiota, serum metabolites, and fecal SCFAs. Overall, these findings will provide a basis for further VSP development.
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- Schisandra sphenanthera, a fruit used in traditional medicine, is reported to have beneficial effects on diabetes mellitus (DM) by helping with symptoms like prolonged cough and thirst and may aid in diabetes prevention and control.
- The research aims to uncover how Schisandra Sphenanthera (SDP) works against type 2 diabetes mellitus (T2DM) through various scientific methods like biochemical analysis and metabolite assays.
- Findings reveal that SDP can lower blood glucose levels, improve metabolic functions, and activate specific signaling pathways, ultimately leading to therapeutic effects on T2DM and restoring damage in organs like the liver and pancreas.
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