Background: Vancomycin has been the preferred treatment for MRSA infections. However, newer drugs are necessary due to the increasing prevalence of MRSA isolates that are less susceptible to vancomycin. Levonadifloxacin its a prodrug alalevonadifloxacin, novel quinolones with broad spectrum anti-MRSA activity. They are approved in India for the treatment of skin and soft-tissue infections, bacteraemia, and diabetic foot infections.
Materials And Methods: A total of 456 MRSA (Methicillin-resistant Staphylococcus aureus) isolates, including 333 isolates from JIPMER and 123 isolates from other tertiary care centers collected between January to December 2022, underwent susceptibility testing to levonadifloxacin by disc diffusion method. The study isolates included 29 h-VISA. Fifty one blood isolates were also subjected to E-test and their results were compared to the gold standard, broth micro dilution (BMD). RESUL: t: All 456 isolates were found to be susceptible to levonadifloxacin by disc diffusion. Levonadifloxacin demonstrated potent activity against MRSA strains isolated from blood (n=51) with an MIC and MIC of 0.38 and 0.5 μg/mL by E-test, respectively. Similarly, it demonstrated an MIC and MIC of 0.5 & 1 μg/ml by BMD.
Conclusion: The present study demonstrated 100% susceptibility to levonadifloxacin among the tested isolates of MRSA, highlighting its promising clinical potential for treating infections caused by this organism. Furthermore, the study recorded a concordance of 100% between disc diffusion and E-test method with BMD, indicating the reliability of these methods.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijmmb.2025.100788 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In vitro efficacy of levonadifloxacin against methicillin-resistant Staphylococcus aureus (MRSA) including hVISA isolates collected across India.
Indian J Med Microbiol
January 2025
Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India; Central Research Lab, Sri Venkateswaraa Medical College Hospital and Research Centre, Ariyur , Puducherry, India. Electronic address:
Background: Vancomycin has been the preferred treatment for MRSA infections. However, newer drugs are necessary due to the increasing prevalence of MRSA isolates that are less susceptible to vancomycin. Levonadifloxacin its a prodrug alalevonadifloxacin, novel quinolones with broad spectrum anti-MRSA activity.
View Article and Find Full Text PDFIntroduction Urinary tract infections (UTIs) are one of the most common bacterial infections encountered in community and healthcare settings. Increasing antimicrobial resistance patterns worldwide have limited the treatment options available. Overuse of carbapenems which were considered as the last resort for multi-drug resistant UTIs over the past decade has led to the emergence of carbapenem-resistant Enterobacterales (CRE).
View Article and Find Full Text PDFAssessment of the Antimicrobial Effect of Momordica charantia (Bitter Gourd Oil) on Periodontal Pathogens: An In Vitro Study.
Cureus
December 2024
Department of Periodontology, Karpaga Vinayaga Institute of Dental Sciences, Chengalpet, IND.
Background Chronic periodontitis is primarily caused by various bacterial species present in the plaque biofilm, which trigger a host inflammatory response. This leads to the abnormal release of inflammatory mediators such as proinflammatory cytokines (interleukin-1, interleukin-6, interleukin-8, and tumor necrosis factor-α), which are free radicals that cause alveolar bone resorption and tooth loss. (bitter gourd) is a widely used medicinal plant for the treatment of numerous diseases such as skin infections, diabetes, metabolic disorders, and carcinomas for several decades.
View Article and Find Full Text PDFAmikacin-loaded selenium nanoparticles improved antibacterial and antibiofilm activity of amikacin against bovine mastitis-causing .
Heliyon
January 2025
Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.
Background: Antibiotic resistance in various microorganisms has become one of the most serious health problems worldwide. The use of nanoparticles in combination with conventional antibiotics is one of the recent efforts to overcome these challenges. This study aims to synthesize and evaluate the possibility of using amikacin-loaded selenium nanoparticles as antibacterial agent against multidrug-resistant , that causes bovine mastitis.
View Article and Find Full Text PDFIn vitro Antioxidant and Antibacterial Activities, Bioactive Compounds, Organic Acids, Sugars, Micro- and Macro-elements of Aquilaria agallocha Root Organic Extracts.
J Oleo Sci
January 2025
Çumra Vocational School, Department of Medicinal and Aromatic Plants, Selcuk University.
Article Synopsis
- Aquilaria agallocha is a valuable yet endangered plant known for producing agarwood, with parts containing medicinal and aromatic properties.
- The study focused on the phytochemical analysis of A. agallocha roots, revealing significant levels of phenolic compounds, organic acids, and sugars, and strong antioxidant capacity.
- The roots showed antibacterial activity against various gram-positive bacteria but were ineffective against gram-negative ones, highlighting their potential for medicinal use.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!