Highly stereo- and enantioselective synthesis of δ-alkyl-substituted ()-homoallylic alcohols via asymmetric allylation is developed. In the presence of a chiral phosphoric acid catalyst, allylation of aldehydes with α-substituted allylboronates provides δ-alkyl-substituted homoallylic alcohols with excellent ()-selectivities and enantioselectivities.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744790 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.4c04401 | DOI Listing |
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