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Acne vulgaris is one of the most common skin diseases worldwide and affects a large population of patients. Post-acne scarring can pose a significant psychosocial burden on patients of all ages; therefore, treatment approaches must be both rapid-acting and effective. Microneedling is a minimally invasive technology that involves the creation of controlled tissue microinjury and subsequent induction of collagen production and tissue remodeling. Platelet-rich plasma (PRP) is an autologous preparation of plasma containing supraphysiologic concentrations of platelets, growth factors, and cytokines. The combination of microneedling and PRP therapy has been postulated to offer synergistic effects in the treatment of acne scarring. The purpose of this review is to critically analyze recent clinical trials that compare the efficacy of microneedling monotherapy to the combination of PRP and microneedling for the treatment of atrophic acne scarring. J Drugs Dermatol. 2025;24(1):41-46. doi:10.36849/JDD.8585R1.
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