AI Article Synopsis
- A method was developed to model liver cirrhosis in male Wistar rats by performing a significant liver resection (about 70% volume).
- After surgery, one group received ademetionine while the control group got saline; both had various tests conducted on them over a 14-day period.
- Results indicated that the ademetionine group experienced notable liver dysfunction, with laboratory tests showing significant abnormalities, along with observable fibrotic, cirrhotic, and inflammatory liver changes that persisted beyond the testing period.
Article Abstract
A method of intraoperative modeling of liver cirrhosis in an experiment has been developed. Mature male Wistar rats underwent typical liver resection (~70% of the initial volume). After resection, intrahepatic injection of 1 ml ademetionine was performed (controls received 0.9% NaCl in the same volume). On days 1, 5, 7, and 14 after surgery, the blood and tissue samples were taken, then the animals were euthanized. Laboratory tests revealed significant deviations in the indicators of cytolysis, cholestasis, and liver cell insufficiency syndromes in the experimental group. Morphological study showed a decrease in the number of mitoses, the development of fibrotic, cirrhotic, and inflammatory changes in the liver. After intrahepatic administration of ademetionine, significant liver dysfunction was observed that did not recover by day 14 after resection, pronounced shifts in laboratory parameters, as well as the development of fibrous, cirrhotic, and inflammatory liver changes.
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| http://dx.doi.org/10.1007/s10517-025-06319-9 | DOI Listing |
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