AI Article Synopsis
- MRI with radial scanning was used to create detailed images of rat lungs, both healthy and those with pulmonary hypertension.
- The retrospective gating method enabled the analysis of lung function during different breathing phases, revealing decreased lung volumes and tidal volumes in the rats with pulmonary hypertension.
- Ventilation maps indicated a significant reduction in airflow in the affected areas, showcasing the method's effectiveness in assessing lung pathology and its influence on respiratory function.
Article Abstract
Using magnetic resonance imaging (MRI) with radial scanning, images of intact rat lungs and rat lungs with pulmonary hypertension were obtained. The retrospective gating method was applied to construct images of rat lungs during inspiration and expiration phases. Lung volumes at both respiratory phases, relative tidal volume, and the percentage of lung lesions were calculated. Lung volumes at inspiration and expiration were greater by ~4 and ~18%, respectively, and the relative lung tidal volume was lower by ~2.8 times than in intact rats. Constructed fractional ventilation maps showed a ~2.6-fold decrease in ventilation values in the pathological area. Thus, the application of the retrospective gating method allows detecting changes in lung volumes and ventilation, confirming the presence of pathology and its impact on the respiratory function.
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