AI Article Synopsis
- The study examined lipid and carbohydrate metabolism as well as adipokines and growth factors in three mouse models with different metabolic disorders: alimentary obesity, leptin-resistant obesity, and diabetes mellitus.
- In the alimentary obesity model, mice showed moderate liver fat, enlarged adipose tissue, and elevated levels of glucose, adiponectin, and cholesterol.
- In the leptin-resistant model, severe tissue issues were noted, along with high blood sugar and leptin but low triglycerides and certain growth factors.
- The diabetes mellitus model revealed a decrease in insulin-producing cells and lower levels of important hormones like adiponectin and leptin, along with high insulin levels.
Article Abstract
Changes in the lipid and carbohydrate metabolism, adipokines, and growth factors during the development of metabolic disorders were studied in three mouse models: C57BL/6 (alimentary obesity), db/db (leptin-resistant obesity), and NOD (diabetes mellitus) lines. In the group of alimentary obesity, moderate fatty infiltration of the liver and hypertrophy of the adipose tissue, hyperglycemia, and increased concentrations of adiponectin, transforming growth factor β1 (TGF-β1), leptin, and cholesterol were detected. In the group of leptin-resistant obesity, multiple pathological changes in tissues, severe hyperglycemia and hyperleptinemia, hyperinsulinemia, and reduced concentrations of triglycerides, adiponectin, myostatin, and TGF-β1 were detected. In NOD mice, reduced number of insulin-positive β cells, hyperinsulinemia, and a decrease in adiponectin, TGF-β1, leptin, and myostatin concentrations were detected.
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| http://dx.doi.org/10.1007/s10517-025-06321-1 | DOI Listing |
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