AI Article Synopsis
- Cellular senescence is the process where cells permanently stop dividing and secrete inflammatory factors, known as the senescence-associated secretory phenotype (SASP), which can contribute to aging and diseases.
- Recent studies show that senescent cells can also play important roles in tumor suppression, tissue development, and repair, highlighting their dual nature.
- The review discusses potential therapies called senolytic agents that target harmful senescent cells while balancing the benefits of transient senescence to improve health as we age.
Article Abstract
As the global population continues to age, understanding the complex role of cellular senescence and its implications in healthy lifespans has gained increasing prominence. Cellular senescence is defined as the irreversible cessation of cell proliferation, accompanied by the secretion of a range of pro-inflammatory factors, collectively termed the senescence-associated secretory phenotype (SASP), in response to various cellular stresses. While the accumulation of senescent cells has been strongly implicated in the aging process and the pathogenesis of age-related diseases owing to their pro-inflammatory properties, recent research has also highlighted their essential roles in processes such as tumour suppression, tissue development, and repair. This review provides a comprehensive examination of the dual nature of senescent cells, evaluating their deleterious contributions to chronic inflammation, tissue dysfunction, and disease, as well as their beneficial roles in maintaining physiological homeostasis. Additionally, we explored the therapeutic potential of senolytic agents designed to selectively eliminate detrimental senescent cells while considering the delicate balance between transient and beneficial senescence and the persistence of pathological senescence. A deeper understanding of these dynamics is critical to develop novel interventions aimed at mitigating age-related dysfunctions and enhancing healthy life expectancies.
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| http://dx.doi.org/10.1093/jb/mvae098 | DOI Listing |
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