Autopsy-related histomorphological findings in neonatal sepsis: a narrative review.

Forensic Sci Med Pathol

Centre for Foetal and Perinatal Pathology, Department of Pathology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Published: January 2025

AI Article Synopsis

  • Neonatal sepsis significantly impacts the health and survival of newborns, posing challenges in accurate diagnosis and understanding the disease's causes.
  • Conventional diagnostic autopsy (CDA) offers valuable insights into the structural changes in organs due to neonatal sepsis, yet there is limited research on these specific histomorphological features.
  • This review seeks to compile existing literature on autopsy findings related to neonatal sepsis to enhance understanding of the disease's effects on different organs and assist pathologists in determining causes of death.

Article Abstract

Neonatal sepsis is an important concern in the field of neonatology, contributing significantly to morbidity and mortality among newborns worldwide. Despite progress in medical care, the accurate diagnosis and comprehension of the pathological underpinnings of neonatal sepsis continue to present challenges. Conventional diagnostic autopsy (CDA) provides unique opportunities to gain insights into the histomorphological alterations associated with neonatal sepsis. There is a paucity of literature regarding autopsy-related histomorphological features in neonatal sepsis in various organs. This narrative review aims to glean data from published literature concerning autopsy-related histomorphological findings in neonatal sepsis, which would aid in understanding organ-related pathological changes and assisting pathologists in determining the exact cause of death.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12024-024-00936-yDOI Listing

Publication Analysis

Top Keywords

neonatal sepsis
24
autopsy-related histomorphological
12
histomorphological findings
8
findings neonatal
8
narrative review
8
neonatal
6
sepsis
6
sepsis narrative
4
review neonatal
4
sepsis concern
4

Similar Publications

Autopsy-related histomorphological findings in neonatal sepsis: a narrative review.

Forensic Sci Med Pathol

January 2025

Centre for Foetal and Perinatal Pathology, Department of Pathology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Article Synopsis
  • Neonatal sepsis significantly impacts the health and survival of newborns, posing challenges in accurate diagnosis and understanding the disease's causes.
  • Conventional diagnostic autopsy (CDA) offers valuable insights into the structural changes in organs due to neonatal sepsis, yet there is limited research on these specific histomorphological features.
  • This review seeks to compile existing literature on autopsy findings related to neonatal sepsis to enhance understanding of the disease's effects on different organs and assist pathologists in determining causes of death.
View Article and Find Full Text PDF
Article Synopsis
  • Observational studies show that using high-flow nasal cannula (HFNC) from 2013-2016 is linked to longer oxygen therapy duration, increased rates of bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP).
  • The study aimed to analyze neonatal outcomes for very preterm newborns with HFNC between 2017-2021, using statistical methods to compare cases with controls based on weight and gestational age.
  • Results indicated a significant rise in BPD and ROP in the HFNC group, alongside higher respiratory support, with logistic regression confirming HFNC use is associated with greater risks for both conditions, suggesting the need for a quality improvement program to enhance HFNC
View Article and Find Full Text PDF

Foals born alive from mares with ultrasonographically assessed placental abnormalities: Neonatal health and development up to weaning compared to foals from healthy mares.

Theriogenology

December 2024

Clinic for Horses - Unit for Reproductive Medicine, University of Veterinary Medicine, Hannover, Foundation, Buenteweg 15, 30559 Hanover, Germany; ReproTraining, Rolandstrasse 62, 33415 Verl, Germany. Electronic address:

Article Synopsis
  • The study compares the neonatal health and development of foals born from mares with ultrasonographically assessed placental abnormalities (UPA) to those born from healthy mares in the same warmblood stud.
  • Foals from UPA mares displayed shorter gestation lengths and lower birth weights, along with poorer colostrum quality, affecting their immunoglobulin G levels and leading to more frequent administration of foreign plasma compared to foals from healthy mares.
  • Additionally, 8.1% of foals from UPA pregnancies exhibited maladjustment syndrome, whereas none in the control group did, indicating potential health risks associated with placental disease.
View Article and Find Full Text PDF

Introduction: Preterm birth (PTB) is associated with newborn morbidity and mortality. DNA methylation plays an important role in the development of fetus, thus can also serve as an epigenetic biomarker. Limited epigenetic studies were conducted in regard to PTB.

View Article and Find Full Text PDF
Article Synopsis
  • Neonatal sepsis is a major cause of newborn deaths in low and middle-income countries, prompting a study in Vietnam to analyze bacterial causes and antibiotic resistance patterns.
  • A study at the National Children's Hospital identified 202 cases of sepsis, predominantly caused by Gram-negative bacteria, with Klebsiella pneumoniae as the most common pathogen.
  • The research underscores the need for ongoing monitoring and specific antibiotic strategies to effectively address neonatal sepsis and its challenges.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!