AI Article Synopsis
- The study identified cytotoxic compounds, falcarinol and falcarindiol, from the roots of Glehnia littoralis, effective against both sensitive and resistant colorectal and lung cancer cells.
- Researchers isolated 13 polyacetylenes, including a new compound (3R,11R)-11-hyroxy-isofalcarinolone, using advanced chemical analysis techniques.
- Findings suggest that while these compounds show potential for anticancer development, their stability needs further investigation since some newly purified compounds did not exhibit expected activity.
Article Abstract
In the preliminary screening, falcarinol and falcarindiol, C polyacetylenes from the roots of Glehnia littoralis F. Schmidt ex Miq (Umbelliferae), displayed cytotoxic activity both against oxaliplatin-sensitive/resistant colorectal cancer (CRC) and gefitinib-sensitive/resistant non-small cell lung cancer (NSCLC) cells. In this study, 13 polyacetylenes including a new (3R,11R)-11-hyroxy-isofalcarinolone (1) were isolated from G. littoralis, and the chemical structures were elucidated through NMR, HRMS, and optical rotation analysis as well as DP4 plus calculation. (3S,8S)-Oplopandiol (5) showed cytotoxic activities against oxaliplatin-sensitive and -resistant CRC (HCT116 and HCT116-OxR) cells. Unexpectedly, (3R,8S)-falcarindiol (3) and (3S)-falcarinol (12), newly purified from G. littoralis, did not show cytotoxic activity. It was confirmed that both falcarinol and falcarindiol, previously evaluated, were decomposed, which seems to be the cause of inconsistent biological results. These findings indicated that C polyacetylene could be a good starting compound for the development of anticancer leads against drug-resistant CRC and NSCLC cells, however, the stability of C polyacetylens should be considered for further studies.
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| http://dx.doi.org/10.1007/s11418-024-01870-7 | DOI Listing |
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