AI Article Synopsis

  • Intestinal tuberculosis accounts for 10% of extrapulmonary TB cases and is often confused with other gastrointestinal diseases like Crohn's Disease due to similar symptoms.
  • Diagnosing this infection is challenging because it has few bacteria present, making it hard to identify.
  • A case study of a 57-year-old patient initially diagnosed with Crohn's Disease showed no improvement with treatment, leading to a later diagnosis of Intestinal Tuberculosis, which improved with the right therapy.

Article Abstract

Intestinal tuberculosis is a bacterial infection that represents 10% of extrapulmonary tuberculosis. It is known as the great mimicker due to its clinical presentation similar to other diseases such as Crohn's Disease or Neoplastic Intestinal Disease. Its diagnosis is complex, given the paucibacillary characteristic of the disease. We present the case of a 57-year-old patient with an initial diagnosis of Crohn's Disease, starting immunosuppressive therapy. After no response to the initial therapy and with a new endoscopic and anatomopathological study, Intestinal Tuberculosis was concluded, which after starting therapy evolved favorably.

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http://dx.doi.org/10.4067/s0034-98872024000600730DOI Listing

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Article Synopsis
  • Intestinal tuberculosis accounts for 10% of extrapulmonary TB cases and is often confused with other gastrointestinal diseases like Crohn's Disease due to similar symptoms.
  • Diagnosing this infection is challenging because it has few bacteria present, making it hard to identify.
  • A case study of a 57-year-old patient initially diagnosed with Crohn's Disease showed no improvement with treatment, leading to a later diagnosis of Intestinal Tuberculosis, which improved with the right therapy.
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Diagnostic value of SAT-TB in stool and urine samples for intestinal and urinary tuberculosis.

Diagn Microbiol Infect Dis

December 2024

State Key Laboratory of Respiratory Disease, Guangzhou Key Laboratory of Tuberculosis Research, Department of Tuberculosis, Guangzhou Chest Hospital, Institute of Tuberculosis, Guangzhou Medical University, Guangdong 510095, PR China. Electronic address:

Background: The simultaneous amplification/testing for tuberculosis (SAT-TB) targets specific 16s rRNA for detecting Mycobacterium tuberculosis in real-time.

Objective: To evaluate SAT-TB's performance in detecting intestinal and urinary TB using stool and urine samples.

Methods: Stool (94) and urine samples (69) (From 2021 to 2022), were collected from pulmonary combined with suspected intestinal or urinary tuberculosis.

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The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

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This case is relevant for describing a rare presentation of intestinal tuberculosis with perianal manifestations, complicated by abscesses and recurrent fistulas. The clinical manifestations mimicked Crohn's disease and other inflammatory conditions, making the diagnosis challenging and requiring a differentiated and meticulous diagnostic process. A 45-year-old male patient presented with a chronic abscess in the left buttock lasting for two years, characterized by spontaneous purulent drainage and multiple recurrences despite surgical and clinical treatments.

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The underlying mechanisms used by the intestinal microbiota to shape disease outcomes of the host are poorly understood. Here, we show that the gut commensal protozoan, Tritrichomonas musculis (T.mu), remotely shapes the lung immune landscape to facilitate perivascular shielding of the airways by eosinophils.

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