AI Article Synopsis
- Hydrogen peroxide and similar substances can harm cellular structures, making natural peroxidases essential but expensive and unstable for detoxifying them.
- Researchers synthesized and tested different compositions of Ce-doped MIL-101(Fe)-NH and MIL-101(Fe)-NO materials for their peroxidase-like activities, with surprising results contradicting previous studies.
- The Ce-doped metal-organic framework showed improved performance as a sensitive colorimetric sensor for detecting hydrogen peroxide and ascorbic acid, analyzing mechanisms through computational methods.
Article Abstract
Hydrogen peroxide, phenols, amines, aldehydes, and other substances can easily damage intracellular biomacromolecules. Although natural peroxidases can convert these harmful substances into benign ones, the high costs, poor stabilities, and stringent application conditions associated with these enzymes necessitate the exploration of artificial mimics. In this study, Ce-doped MIL-101(Fe)-NH and MIL-101(Fe)-NO were synthesized with varying compositions a solvothermal method. The materials were characterized, and their peroxidase-like activities were compared under optimal conditions after optimizing the reaction conditions. Previous studies have suggested that the undoped MIL-101(Fe)-NO exhibits a superior peroxidase-like activity to that of the undoped MIL-101(Fe)-NH. Our experimental results demonstrated the opposite trend, in stark contrast to previous findings. Based on these experiments, the fundamental processes were examined through computational methods. The Ce-doped Fe metal-organic framework exhibited lower detection limits and wider detection ranges for hydrogen peroxide and ascorbic acid when used as a sensitive colorimetric sensor.
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| http://dx.doi.org/10.1039/d4dt03111c | DOI Listing |
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