AI Article Synopsis
- Developed a 3-D acoustic radiation force impulse (ARFI) system for prostate imaging to identify cancerous regions and guide biopsies in one visit using a transrectal probe and 3-D visualization software.
- The system was tested in a clinical trial comparing ARFI-guided targeted transperineal biopsies with other standard biopsy methods.
- Results showed ARFI was less effective for lower-grade cancers but performed well for higher-grade cancers, suggesting it could enhance biopsy accuracy when combined with 2-D imaging techniques.
Article Abstract
We have developed a 3-D acoustic radiation force impulse (ARFI) prostate imaging system to identify regions suspicious for cancer and guide a targeted prostate biopsy in a single visit. The system uses a side-fire transrectal probe and an automated rotation stage to acquire ARFI and B-mode image volumes, combined with 3-D visualization and targeting software to enable biopsy target identification and guide a transperineal (TP) biopsy. The system was tested in the first clinical trial of its kind, with subjects serially undergoing ARFI-guided targeted TP biopsy, multiparametric magnetic resonance imaging (mpMRI)-ultrasound fusion TP biopsy, and systematic sampling TP biopsy. The findings indicate that the ARFI system is feasible for guiding a targeted biopsy. For lower-grade cancer (grade groups [GG] 1-2), ARFI underperformed mpMRI and systematic sampling, detecting cancer in 54% of GG 2 subjects. However, ARFI performance improved with increasing cancer grade; for higher-grade cancer (GG 3-5), ARFI performed comparably to the other biopsy approaches, and detected cancer in all GG 4 and 5 subjects. The findings also suggest the benefit of using 2-D ARFI imaging to confirm target location during live B-mode imaging, which could improve existing ultrasonic fusion biopsy workflows. This study is registered with ClinicalTrials.gov as NCT04607135.
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| http://dx.doi.org/10.1177/01617346241311901 | DOI Listing |
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