Background: More than 50% of people receiving long-term sickness benefits in Denmark have a common mental illness. At the same time, a significant treatment gap exists where less than 30% receive sufficient care for their mental illness.
Methods: The trial was designed as an investigator-initiated, randomized, two-group parallel superiority trial. Nine hundred participants with a common mental illness were randomly assigned into two groups: (1) IBBIS II, consisting of integrated mental health care and vocational rehabilitation, or (2) service as usual (SAU), at two sites in Denmark. The primary outcome was the difference between the two groups in time to return to work (RTW) at 12 months.
Results: There was no difference between the integrated IBBIS II intervention and SAU in time from baseline to RTW at the 12-month follow-up (Hazard ratio (HR) = 1.16 (95% CI 0.99-1.37), = 0.07), but there was a tendency that the IBBIS II group had worse outcomes on several exploratory employment measures, including time to return to work at 6-month follow-up (HR = 1.36 (95% CI 1.03-1.55), = 0.02), and number of weeks in work at 12-month follow-up (incidence rate ratio = 1.14 (95% CI 1.04-1.27), = 0.008).
Discussion: The integrated employment and health intervention (IBBIS II) was not more effective than SAU in any of the included vocational outcomes and may even have been inferior to SAU on certain outcome measures. Based on these results, it is not recommended that the IBBIS II intervention is widely implemented in countries with service as usual comparable with Denmark.
Trial Registration: ClinicalTrials.gov. Registered June 16, 2020, NCT04432129. https://clinicaltrials.gov/ct2/show/NCT04432129?term = IBBIS+II.
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http://dx.doi.org/10.1080/08039488.2024.2446362 | DOI Listing |
The guide extension-facilitated ostial stenting (GEST) technique uses a guide extension catheter (GEC) to improve stent delivery during primary coronary angioplasty (PCI). GECs are used for stent delivery into the coronary arteries of patients with difficult anatomy due to tortuosity, calcification, or chronic total occlusion (CTO) vessels. Stent and balloon placement has become challenging in patients with increasing lesion complexity due to tortuosity, vessel morphology, length of the lesion, and respiratory movements.
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Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, China.
Background: Patients with simultaneous ruptures of the patellar tendon (PT) and anterior cruciate ligament (ACL) underwent PT repair and ACL reconstruction in a single or staged surgery. However, due to the limited cases, the design of previous studies was mostly case report with varying conclusions regarding recommended surgical strategy selection, the optimal surgical strategy remains a subject of debate.
Methods: We conducted a retrospective case series and literature review, including 10 cases from local institution and 27 cases from 17 studies.
Sci Rep
January 2025
Department of Pediatric Hematology and Oncology, University Hospital Bonn, Bonn, Germany.
This study aims to explore the long-term follow-up needs and motivations of childhood and adolescent cancer survivors and their parents to attend follow-up care in Germany, given the inconsistent adherence to national follow-up guidelines. We developed interview guidelines based on the Theory of Planned Behavior and the stereotype priming model to explore motivations and barriers related to follow-up care. We conducted a total of 36 episodic narrative interviews with adolescent (ages 13-17) and adult (ages 18-45) survivors of pediatric cancer, as well as their parents.
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January 2025
School of Mines, Jiangsu Engineering Laboratory of Mine Earthquake Monitoring and Prevention, China University of Mining and Technology, Xuzhou, 221116, China.
Aiming at the problems of complex stress and large deformations in the surrounding rocks of the roadway driven under the goafs of small collieries and heading for adjacent advancing coal face, by numerical modeling and field practice, the failure characteristics of the overlying coal and rocks were investigated, and the stopping and resuming times of the roadway excavation were identified. A zoning-based reinforcement technique was put forward and applied in engineering practice. The results showed that (1) The roadway roof was divided into four zones: "Rolid coal zone", "Residual pillar zone", "Roof caved zone", and "Roof un-caved zone".
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Director of Co-Founder and Founder of Schizophrenia Society, University of Cincinnati, Cincinnati, Ohio, USA.
Bipolar disorder often begins in adolescence or early adulthood, characterized by recurrent manic episodes that can lead to neurodegenerative brain changes and functional decline. While several oral second-generation antipsychotics are Food and Drug Administration (FDA)-approved for mania, adherence to maintenance treatment is frequently poor due to factors such as anosognosia, cognitive dysfunction, impulsivity, side effects aversion, and substance use. Long-acting injectable (LAI) antipsychotics, approved for adults with bipolar mania or schizoaffective disorder (bipolar type), offer a potential solution for adolescents with similar conditions.
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