AI Article Synopsis
- The study followed vaccinated healthcare workers over 13 months to evaluate their immune responses to the BNT162b2 mRNA COVID-19 vaccine.
- It found strong initial immune responses after each vaccine dose, but observed a decline over time, indicating a potential need for booster shots.
- Younger participants displayed higher immunoglobulin G levels after the first dose, but these differences were not consistent in subsequent doses, highlighting the importance of maintaining cellular immunity for lasting protection against the virus.
Article Abstract
In this 13-month follow-up study, we examined a cohort of vaccinated healthcare workers without prior SARS-CoV-2 infection to assess the humoral and cellular response to the BNT162b2 mRNA COVID-19 vaccine over time. We measured median immunoglobulin G and lymphocyte subpopulation levels after the first and second doses, at five months post-second dose, and before and after the third dose. Our findings evinced a remarkable initial cellular and humoral response to each vaccine dose, although a progressive decline suggests the potential need for long-term booster doses. Age analysis showed significantly higher immunoglobulin G levels in the younger group after the first dose administration, although these differences were not maintained in the following doses. Preserving cellular immunity could assure long-lasting protection against SARS-CoV-2 infection.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700304 | PMC |
| http://dx.doi.org/10.7759/cureus.75188 | DOI Listing |
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