AI Article Synopsis
- Traumatic brain injury (TBI) is a significant global health issue, leading to digestive dysfunction that complicates recovery and health outcomes.
- The mechanisms affecting digestion post-TBI include inflammation, the enteric nervous system, and hormonal changes, all of which can hinder neurologic recovery through the brain-gut axis.
- The article explores the pathogenesis of digestive issues after TBI, aiming to enhance treatment strategies and the long-term prognosis for patients by improving digestive function through recent technological advancements.
Article Abstract
Traumatic brain injury (TBI) is a prevalent disease that poses a significant threat to global public health. Digestive dysfunction, as a common complication, is of particular importance to understand its pathogenesis, diagnostic criteria, and relevant treatment strategies. TBI can affect digestive function through inflammatory immune responses, the enteric nervous system, and hormonal levels. Furthermore, TBI can also impact neurologic recovery through bidirectional communication along the brain-gut axis. Therefore, this article aims to summarize the underlying mechanisms and further explore individualized feeding strategies, therapeutic approaches, long-term prognosis for TBI patients, as well as recent advancements in related technologies. Further understanding of the pathogenesis of digestive system dysfunction after TBI on the basis of the interaction of gut-brain axis is conducive to more future therapies to treat TBI and improve the long-term prognosis of patients through improving digestive function, and achieve good clinical efficacy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695231 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1524495 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the Research Focus of RNA-Binding Proteins in Trauma and Burns.
Anal Cell Pathol (Amst)
January 2025
Department of Burn Surgery, The First Affiliated Hospital of Naval Medical University, People's Republic of China, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, No. 168 Changhai Road, Shanghai 200433, China.
Trauma and burns are leading causes of death and significant global health concerns. RNA-binding proteins (RBPs) play a crucial role in post-transcriptional gene regulation, influencing various biological processes of cellular RNAs. This study aims to review the emerging trends and key areas of research on RBPs in the context of trauma and burns.
View Article and Find Full Text PDFTraumatic brain injury (TBI) is a leading cause of mortality and disability worldwide and can lead to secondary sequelae such as increased seizure susceptibility. Emerging work suggests that the thalamus, the relay center of the brain that undergoes secondary damage after cortical TBI, is involved with heightened seizure risks after TBI. TBI also induces the recruitment of peripheral immune cells, including T cells, to the site(s) of injury, but it is unclear how these cells impact neurological sequelae post-TBI.
View Article and Find Full Text PDFTrauma and the default mode network: review and exploratory study.
Front Behav Neurosci
December 2024
Center for Neuropsychology and Consciousness, Miami, FL, United States.
While PTSD continues to be researched in great depth, less attention has been given to the continuum of traumatic responses that resides outside this diagnosis. This investigation begins with a literature review examining the spectrum of responses through the lens of the default mode network (DMN). To build upon this literature, a systematic exploratory study was incorporated, examining DMN-related neuropsychological functioning of 27 participants (16 trauma-exposed, and 11 non-trauma-exposed), with a subset (15 participants) completing neuroimaging.
View Article and Find Full Text PDFOnly skull-deep? Headbutting adaptations may not extend to the brain cavity.
Anat Rec (Hoboken)
January 2025
Center for Anatomy and Functional Morphology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
High-impact headbutting behavior makes the muskox (Ovibos moschatus) a charismatic species. While many theorize how these headbutting bovids might protect their brain during such encounters, few have investigated their claims anatomically. We investigated the anatomical function of digitiform impressions in the bovid brain cavity and their relationship to headbutting.
View Article and Find Full Text PDFAssociation between cerebral oxygenation and usual parameters of cerebral perfusion in critically ill patients with acute brain injury.
J Cereb Blood Flow Metab
January 2025
AP-HP, Hôpital Lariboisière, Department of Anaesthesia and Critical Care, Paris, France.
In patients with acute brain injury (ABI), optimizing cerebral perfusion parameters relies on multimodal monitoring. This include data from systemic monitoring-mean arterial pressure (MAP), arterial carbon dioxide tension (PaCO), arterial oxygen saturation (SaO), hemoglobin levels (Hb), and temperature-as well as neurological monitoring-intracranial pressure (ICP), cerebral perfusion pressure (CPP), and transcranial Doppler (TCD) velocities. We hypothesized that these parameters alone were not sufficient to assess the risk of cerebral ischemia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!