The global food system is plagued by legitimacy and stability issues due to climate and ecosystem disruptions, contributing to widespread malnutrition. A significant portion of the global population experiences undernourishment, overweight, and micronutrient deficiencies from unhealthy diets. Addressing these challenges necessitates regular consumption of essential nutrients from plant sources. Among various crops, leaves are highly nutritious, offering essential vitamins, minerals, and medicinal properties. Whence research was conducted to inquire the proximate phytochemical composition and extraction efficiency of moringa leaf extracts across four extraction methods: maceration (E), Soxhlet (E), ultrasound-assisted extraction (UAE) (E), and microwave-assisted extraction (MAE) (E) using 70 % hydro-ethanolic solvent. The study detected the presence of phytocompounds and phytonutrients at higher levels in UAE and MAE extracts. Recovery yield was highest for UAE (21.81 ± 0.32 %) than conventional extraction methods (6.24 ± 0.08 %). Both advanced extraction methods resulted in higher TPC (148.86 ± 1.92 mg GAE/g and 137.65 ± 4.49 mg GAE/g, respectively) and TFC (23.18 ± 0.44 mgQE/g and 22.12 ± 0.61 mg QE/g, respectively). Protein and ascorbic acid contents followed a similar trend, with UAE achieving 148.66 ± 3.74 mg/ml and 620.25 ± 1.42 mg/100g, respectively. Antioxidant activity measured by DPPH assay was highest in UAE (86.25 ± 1.58 %) along with the lowest IC values (11.62 ± 1.58 μg/ml) in UAE. Furthermore, ICP-OES analysis revealed higher concentrations of essential phyto-minerals in moringa leaf extracts. Moreover, SEM analysis revealed significant morphological disruptions in the leaf samples, correlating with higher phytomolecules recovery. The outcome of the research is that novel extraction methods significantly enhanced the extraction efficiency and quality of bioactive compounds from moringa leaves, suggesting their potential in the development of nutraceutical and biofortified food products to expunge malnutrition.
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http://dx.doi.org/10.1016/j.heliyon.2024.e40909 | DOI Listing |
J Med Econ
January 2025
UNESCO-TWAS, The World Academy of Sciences, Trieste, Italy.
Aim: Dynamic cancer control is a current health system priority, yet methods for achieving it are lacking. This study aims to review the application of system dynamics modeling (SDM) on cancer control and evaluate the research quality.
Methods: Articles were searched in PubMed, Web of Science, and Scopus from the inception of the study to November 15th, 2023.
J Esthet Restor Dent
January 2025
Department of Prosthodontics, Propaedeutics and Dental Materials, School of Dentistry, Christian-Albrechts University at Kiel, Kiel, Germany.
Objective: Investigation of the mechanical properties of occlusal veneers made from zirconia with varying translucency, bonded to different tooth substrates.
Materials And Methods: Sixty-four extracted molars were divided into two groups: preparation within enamel (E) or extending into dentin (D). Veneers were milled from four zirconia ceramics (n = 8): 5Y-TZP (HT), a multilayer of 5 and 3Y-TZP (GT), 3Y-TZP (LT), and 4Y-TZP (MT).
Scand J Gastroenterol
January 2025
Norwegian PSC Research Centre, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Objectives: Indications of mitochondrial dysfunction are commonly seen in liver diseases, but data are scarce in primary sclerosing cholangitis (PSC). Analyzing circulating and liver-resident molecules indirectly reflecting mitochondrial dysfunction, we aimed to comprehensively characterize this deficit in PSC, and whether this was PSC specific or associated with cholestasis.
Materials And Methods: We retrospectively included plasma from 191 non-transplant patients with large-duct PSC and 100 healthy controls and explanted liver tissue extracts from 24 PSC patients and 18 non-cholestatic liver disease controls.
EClinicalMedicine
October 2024
Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Center, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada.
Background: Use of health applications (apps) to support healthy lifestyles has intensified. Different app features may support effectiveness, including gamification defined as the use of game elements in a non-game situation. Whether health apps with gamification can impact behaviour change and cardiometabolic risk factors remains unknown.
View Article and Find Full Text PDFHum Reprod Open
November 2024
Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Study Question: How accurately can artificial intelligence (AI) models predict sperm retrieval in non-obstructive azoospermia (NOA) patients undergoing micro-testicular sperm extraction (m-TESE) surgery?
Summary Answer: AI predictive models hold significant promise in predicting successful sperm retrieval in NOA patients undergoing m-TESE, although limitations regarding variability of study designs, small sample sizes, and a lack of validation studies restrict the overall generalizability of studies in this area.
What Is Known Already: Previous studies have explored various predictors of successful sperm retrieval in m-TESE, including clinical and hormonal factors. However, no consistent predictive model has yet been established.
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